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New chiral stationary phase with macrocyclic glycopeptide Z-D antibiotic eremomycin chemically bonded to silica

Citation

Staroverov S, SM and Kuznetsov, MA and Nesterenko, PN and Vasiarov, GG and Katruha, GS and Fedorova, GB, New chiral stationary phase with macrocyclic glycopeptide Z-D antibiotic eremomycin chemically bonded to silica, Journal of Chromatography A, 1108, (2) pp. 263-267. ISSN 0021-9673 (2006) [Refereed Article]

DOI: doi:10.1016/j.chroma.2006.01.073

Abstract

A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity. © 2006 Elsevier B.V. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Nesterenko, PN (Professor Pavel Nesterenko)
ID Code:47756
Year Published:2006
Web of Science® Times Cited:29
Deposited By:Chemistry
Deposited On:2007-09-20
Last Modified:2011-10-24
Downloads:0

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