eCite Digital Repository

Fire ecology


Bowman, DMJS and Boggs, GS, Fire ecology, Progress in Physical Geography, 30, (2) pp. 245-257. (2006) [Substantial Review]

DOI: doi:10.1191/0309133306pp482pr


Purpose of review: Interleukin-12 is a heterodimeric cytokine and an important mediator of the cellular immune response. The recent discovery of the novel cytokine interleukin-23 has led to a re-evaluation of interleukin-12 biology, as both cytokines use a common p40 subunit. This review discusses understanding of what distinguishes these related cytokines and the infection risks associated with targeting these cytokine pathways during treatment of inflammatory diseases. Recent findings: Recent work has shown that interleukin-23 stimulates the development of a distinct subset of effector T cells that produce interleukin-17A. These interleukin-17A-producing cells are critical mediators of the inflammatory response in several mouse models of autoimmunity. Although it is well established that interleukin-12 is a critical mediator of host defense, the role of the interleukin-23/interleukin-17A axis during infections has only recently been evaluated. Summary: Interleukin-12 and interleukin-23 have distinct roles in mediating host defense and autoimmune inflammation. Although targeting interleukin-12 and interleukin-23 simultaneously against the common p40 subunit is efficacious in clinical trials for human autoimmune diseases, targeting of interleukin-23 alone or the downstream effector cytokine interleukin-17A may be an effective treatment strategy for organ-specific autoimmune diseases. It is likely that targeting interleukin-23 or interleukin-17A alone, as opposed to targeting interleukin-12 and interleukin-23 together, will reduce the patients' risk of developing treatment-related infections. © 2006 Lippincott Williams & Wilkins.

Item Details

Item Type:Substantial Review
Research Division:Biological Sciences
Research Group:Other biological sciences
Research Field:Global change biology
Objective Division:Environmental Policy, Climate Change and Natural Hazards
Objective Group:Adaptation to climate change
Objective Field:Social impacts of climate change and variability
UTAS Author:Bowman, DMJS (Professor David Bowman)
ID Code:47618
Year Published:2006
Web of Science® Times Cited:8
Deposited By:Plant Science
Deposited On:2007-09-19
Last Modified:2011-06-07

Repository Staff Only: item control page