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Separation of homologues of organic compounds using the gradient of the eluent flow rate on a monolithic porous column
journal contribution
posted on 2023-05-16, 20:02 authored by Nesterenko, PN, Rybalko, MAThe use of the gradient of the eluent flow rate is proposed for the optimization of separation in high-performance liquid chromatography (HPLC). This approach was used for the separation of the homologues of polycyclic aromatic compounds and di-n-alkyl phthalates on monolithic porous silica gel Chromolith (Merck, Germany) with modifying octadecyl radicals by reversed-phase HPLC. The principle of the optimization of the gradient of the eluent flow rate for the separation of the homologues of organic compounds was formulated on the basis of peculiarities in their chromatographic retention. It was demonstrated that using the gradient of the flow rate provides the selective and efficient separation of homologues and a significant decrease in the time of separation. © 2005 Pleiades Publishing, Inc.
History
Publication title
Journal of Analytical ChemistryVolume
60Issue
4Pagination
349-354ISSN
1061-9348Department/School
School of Natural SciencesPublisher
MAIK Nauka - InterperiodicaPlace of publication
Russian FederationRepository Status
- Restricted