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Adolescent exposure to high-dose estrogen and subsequent effects on lactation


Jordan, HL and Bruinsma, FJ and Thomson, RJ and Amir, LH and Werther, GA and Venn, A, Adolescent exposure to high-dose estrogen and subsequent effects on lactation, Reproductive Toxicology , 24, (3-4) pp. 397-402. ISSN 0890-6238 (2007) [Refereed Article]

DOI: doi:10.1016/j.reprotox.2007.04.001


Treatment with high-dose estrogens has been used to reduce the adult height of tall girls for many years. Short-term side effects on the breast have been reported but there have been no studies to investigate whether there are long-term effects on lactation. This retrospective cohort study of 371 treated and 409 untreated women asked about breastfeeding history. After adjusting for maternal age at first live-birth, treated women (4.4%) were no more likely than untreated women (4.1%) to not commence breastfeeding (RR 1.13, 95% CI 0.50-2.52). After adjusting for age, there was no significant difference in the average duration of breastfeeding between treated (median 41.1 weeks) and untreated women (median 43.3 weeks) (p = 0.77) for all live-births. Treated women were not significantly more likely to report physiological reasons for stopping breastfeeding than untreated women. Women treated with high-dose estrogens during adolescence appeared to be no different to untreated women in their ability to lactate. © 2007 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Women's and maternal health
UTAS Author:Jordan, HL (Ms Helen Jordan)
UTAS Author:Thomson, RJ (Dr Russell Thomson)
UTAS Author:Venn, A (Professor Alison Venn)
ID Code:47504
Year Published:2007
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2008-05-13

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