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The lack of effect of isoflavones on high-density lipoprotein cholesterol concentrations in adolescent boys: a 6-week randomised trial
Citation
Dwyer, T and Hynes, K and Fryer, JL and Blizzard, CL and Dalais, FS, The lack of effect of isoflavones on high-density lipoprotein cholesterol concentrations in adolescent boys: a 6-week randomised trial, Public Health Nutrition, 11, (9) pp. 955-962. ISSN 1368-9800 (2008) [Refereed Article]
DOI: doi:10.1017/S1368980007000869
Abstract
Background: A substantial fall in high-density lipoprotein cholesterol (HDL-C) during puberty in boys, but not girls, has been reported in Western populations. The fall in boys is believed to be due to hormonal changes - androgens have been shown to be associated with lower HDL-C, whereas oestrogens are associated with higher HDL-C. The fall in HDL-C during puberty was not observed, however, in a study of Moslem boys in Israel, nor in a group of Japanese boys. A diet high in phyto-oestrogens may account for the lack of a fall in HDL-C in these populations. Objective: To examine the effect of dietary supplementation with phyto-oestrogens on the HDL-C concentration of adolescent boys from a Western population. We hypothesised that dietary supplementation of 50 mg of the isoflavones daidzein and genistein would produce a 12% higher HDL-C concentration than in controls at the end of a 6-week intervention period. Design: A randomised controlled trial. Setting: Hellyer College in Burnie (Tasmania, Australia). Subjects: Adolescent boys (aged 16-18 years) were recruited through a letter sent to parents. A total of 132 eligible participants enrolled and five subjects withdrew from the trial. Results: No significant increase in HDL-C was observed in the treatment group (-0.02 mmol l -1, standard error (SE)=0.03, P = 0.53) or the placebo group (0.05 mmol l-1, SE = 0.03, P = 0.11). Conclusions: Factors other than isolated dietary isoflavones may be responsible for the lack of fall in HDL-C during puberty in Japanese and Moslem boys. © The Authors 2007.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Health Sciences |
| Research Group: | Epidemiology |
| Research Field: | Epidemiology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Disease distribution and transmission (incl. surveillance and response) |
| UTAS Author: | Dwyer, T (Professor Terry Dwyer) |
| UTAS Author: | Hynes, K (Dr Kristen Hynes) |
| UTAS Author: | Fryer, JL (Ms Jayne Fryer) |
| UTAS Author: | Blizzard, CL (Professor Leigh Blizzard) |
| ID Code: | 47502 |
| Year Published: | 2008 (online first 2007) |
| Web of Science® Times Cited: | 2 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2007-08-01 |
| Last Modified: | 2014-11-14 |
| Downloads: | 0 |
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