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The association between non-melanoma skin cancer and osteoporotic fractures a population-based record linkage study

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posted on 2023-05-16, 19:56 authored by Srikanth, V, Fryer, JL, Alison VennAlison Venn, Christopher BlizzardChristopher Blizzard, Newman, LA, Cooley, HM, Timothy AlbionTimothy Albion, Graeme JonesGraeme Jones
Summary: We studied the association between osteoporotic fractures and prior non-melanoma skin cancer (NMSC, a biomarker for cumulative sun exposure). The risk of prior NMSC in our fracture cohort was significantly reduced (standardised incidence ratio 0.69, 95% CI 0.61, 0.78). Adequate lifetime sun exposure may be necessary to protect against osteoporotic fractures in later life. Introduction: The relationship between cumulative sun exposure and osteoporotic fractures is uncertain. We aimed to study the association between non-melanoma skin cancer (NMSC), a marker of cumulative sun exposure, and osteoporotic fractures in an older cohort. Methods: A retrospective cohort study in southern Tasmania in people aged at least 50 years with incident radiographic fracture (n=2,283) was carried out. By record linkage to the Tasmanian Cancer Registry the cohort was followed backwards through time until the occurrence of NMSC or end-of follow-up. Relative risk was estimated by the standardised incidence ratio (SIR) using sex-, age- and calendar year-specific cancer incidence rates in southern Tasmania as reference. Results: The incidence of prior NMSC in the fracture cohort was 31% lower than for the general population (SIR 0.69, 95% CI 0.61, 0.78). This effect was significant for most fracture subtypes except pelvic and wrist fractures and observed for both NMSC subtypes, squamous cell carcinoma and basal cell carcinoma. Conclusions: Older people with osteoporotic fractures may have had lifestyles linked to lower cumulative sunlight exposure. Achieving a balance between adequate lifetime sun exposure and protection against its adverse effects (such as fractures and skin cancer) may require assessment of individual risks. © 2007 International Osteoporosis Foundation and National Osteoporosis Foundation.

History

Publication title

Osteoporosis International

Volume

18

Issue

5

Pagination

687-692

ISSN

0937-941X

Department/School

Menzies Institute for Medical Research

Publisher

Springer UK

Place of publication

United Kingdom

Repository Status

  • Restricted

Socio-economic Objectives

Health related to ageing

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