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The association between non-melanoma skin cancer and osteoporotic fractures a population-based record linkage study


Srikanth, V and Fryer, JL and Venn, A and Blizzard, CL and Newman, LA and Cooley, HM and Albion, T and Jones, G, The association between non-melanoma skin cancer and osteoporotic fractures a population-based record linkage study, Osteoporosis International, 18, (5) pp. 687-692. ISSN 0937-941X (2007) [Refereed Article]

DOI: doi:10.1007/s00198-006-0303-y


Summary: We studied the association between osteoporotic fractures and prior non-melanoma skin cancer (NMSC, a biomarker for cumulative sun exposure). The risk of prior NMSC in our fracture cohort was significantly reduced (standardised incidence ratio 0.69, 95% CI 0.61, 0.78). Adequate lifetime sun exposure may be necessary to protect against osteoporotic fractures in later life. Introduction: The relationship between cumulative sun exposure and osteoporotic fractures is uncertain. We aimed to study the association between non-melanoma skin cancer (NMSC), a marker of cumulative sun exposure, and osteoporotic fractures in an older cohort. Methods: A retrospective cohort study in southern Tasmania in people aged at least 50 years with incident radiographic fracture (n=2,283) was carried out. By record linkage to the Tasmanian Cancer Registry the cohort was followed backwards through time until the occurrence of NMSC or end-of follow-up. Relative risk was estimated by the standardised incidence ratio (SIR) using sex-, age- and calendar year-specific cancer incidence rates in southern Tasmania as reference. Results: The incidence of prior NMSC in the fracture cohort was 31% lower than for the general population (SIR 0.69, 95% CI 0.61, 0.78). This effect was significant for most fracture subtypes except pelvic and wrist fractures and observed for both NMSC subtypes, squamous cell carcinoma and basal cell carcinoma. Conclusions: Older people with osteoporotic fractures may have had lifestyles linked to lower cumulative sunlight exposure. Achieving a balance between adequate lifetime sun exposure and protection against its adverse effects (such as fractures and skin cancer) may require assessment of individual risks. © 2007 International Osteoporosis Foundation and National Osteoporosis Foundation.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
UTAS Author:Fryer, JL (Ms Jayne Fryer)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
UTAS Author:Newman, LA (Ms Leah Newman)
UTAS Author:Cooley, HM (Dr Helen Cooley)
UTAS Author:Albion, T (Mr Tim Albion)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:47223
Year Published:2007
Web of Science® Times Cited:14
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2009-09-22

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