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Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology

journal contribution
posted on 2023-05-16, 19:49 authored by Carolyn KingCarolyn King, Jacobs, I, Tracey DicksonTracey Dickson, James VickersJames Vickers
We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club- like axonal changes characterized by an accumulation of neurofilaments. Morphologically and neurochemically identical abnormal axons were present within neocortical β-amyloid deposits of individuals in the early stages of AD. Physically damaged rat cortical axons may therefore serve as a model for the early neuronal pathology of AD. Furthermore, these results suggest that insoluble β-amyloid deposition may physically damage local axons, with further neurofibrillary changes due to the reactive neuronal response to this type of injury.

History

Publication title

Neuroreport

Volume

8

Issue

7

Pagination

1663-1665

ISSN

0959-4965

Department/School

Menzies Institute for Medical Research

Publisher

Lippincott Williams & Wilkins

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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