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Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology


King, CE and Jacobs, I and Dickson, TC and Vickers, JC, Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology, Neuroreport, 8, (7) pp. 1663-1665. ISSN 0959-4965 (1997) [Refereed Article]


We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club- like axonal changes characterized by an accumulation of neurofilaments. Morphologically and neurochemically identical abnormal axons were present within neocortical β-amyloid deposits of individuals in the early stages of AD. Physically damaged rat cortical axons may therefore serve as a model for the early neuronal pathology of AD. Furthermore, these results suggest that insoluble β-amyloid deposition may physically damage local axons, with further neurofibrillary changes due to the reactive neuronal response to this type of injury.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:King, CE (Dr Carolyn King)
UTAS Author:Jacobs, I (Mrs Irene Jacobs)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:46811
Year Published:1997
Web of Science® Times Cited:29
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-09-04
Last Modified:2007-09-04

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