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Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology

Citation

King, CE and Jacobs, I and Dickson, TC and Vickers, JC, Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology, Neuroreport, 8, (7) pp. 1663-1665. ISSN 0959-4965 (1997) [Refereed Article]

Abstract

We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club- like axonal changes characterized by an accumulation of neurofilaments. Morphologically and neurochemically identical abnormal axons were present within neocortical β-amyloid deposits of individuals in the early stages of AD. Physically damaged rat cortical axons may therefore serve as a model for the early neuronal pathology of AD. Furthermore, these results suggest that insoluble β-amyloid deposition may physically damage local axons, with further neurofibrillary changes due to the reactive neuronal response to this type of injury.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:King, CE (Dr Carolyn King)
Author:Jacobs, I (Mrs Irene Jacobs)
Author:Dickson, TC (Professor Tracey Dickson)
Author:Vickers, JC (Professor James Vickers)
ID Code:46811
Year Published:1997
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-09-04
Last Modified:2007-09-04
Downloads:0

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