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Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology
journal contribution
posted on 2023-05-16, 19:49 authored by Carolyn KingCarolyn King, Jacobs, I, Tracey DicksonTracey Dickson, James VickersJames VickersWe investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club- like axonal changes characterized by an accumulation of neurofilaments. Morphologically and neurochemically identical abnormal axons were present within neocortical β-amyloid deposits of individuals in the early stages of AD. Physically damaged rat cortical axons may therefore serve as a model for the early neuronal pathology of AD. Furthermore, these results suggest that insoluble β-amyloid deposition may physically damage local axons, with further neurofibrillary changes due to the reactive neuronal response to this type of injury.
History
Publication title
NeuroreportVolume
8Issue
7Pagination
1663-1665ISSN
0959-4965Department/School
Menzies Institute for Medical ResearchPublisher
Lippincott Williams & WilkinsPlace of publication
USARepository Status
- Restricted