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No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases

Citation

Woodhouse, A and Dickson, TC and West, AK and McLean, CA and Vickers, JC, No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases, Neurobiology of Disease, 22, (2) pp. 323-333. ISSN 0969-9961 (2006) [Refereed Article]

DOI: doi:10.1016/j.nbd.2005.11.010

Abstract

Apoptotic-like changes in the neocortex of control, pathologically aged and Alzheimer's disease (AD) cases were investigated. There was no increase in labeling or change in localization of labeling that distinguished between these cases for active caspase-3, -8, -9, Bax, Bcl-2 or TRADD. Bax, Bcl-2 and TRADD mRNA levels also differed little between case types, although there were small but significant decreases in Bax mRNA levels in AD compared to control cases and Bcl-2 mRNA in AD cases compared to pathologically aged and control cases. There was no difference in the percentage of apoptotic-like nuclei between these cases, except for a small but significant decrease in the inferior temporal gyrus of AD cases relative to controls. Nuclei observed within or adjacent to β-amyloid plaques were rarely abnormal, and neurons bearing neurofibrillary tangles (NFTs) did not have abnormal nuclei. Apoptosis may not play a major role in the pathogenesis of neuronal degeneration of AD. © 2005 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Woodhouse, A (Dr Adele Woodhouse)
Author:Dickson, TC (Professor Tracey Dickson)
Author:West, AK (Professor Adrian West)
Author:Vickers, JC (Professor James Vickers)
ID Code:46808
Year Published:2006
Web of Science® Times Cited:23
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2007-10-16
Downloads:0

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