eCite Digital Repository

Vaccination strategies for Alzheimer's disease: a new hope?

Citation

Woodhouse, A and Dickson, TC and Vickers, JC, Vaccination strategies for Alzheimer's disease: a new hope?, Drugs and Aging, 24, (2) pp. 107-119. ISSN 1170-229X (2007) [Refereed Article]

DOI: doi:10.2165/00002512-200724020-00003

Abstract

The pathological hallmarks of Alzheimer's disease (AD) include β-amyloid (Aβ) plaques, dystrophic neurites and neurofibrillary pathology, which eventually result in the degeneration of neurons and subsequent dementia. In 1999, international interest in a new therapeutic approach to the treatment of AD was ignited following transgenic mouse studies that indicated that it might be possible to immunise against the pathological alterations in Aβ that lead to aggregation of this protein in the brain. A subsequent phase I human trial for safety, tolerability and immunogenicity using an active immunisation strategy against Aβ had a positive outcome. However, phase IIA human trials involving active immunisation were halted following the diagnosis of aseptic meningoencephalitis in 6% of immunised subjects. Research into immunisation strategies involving transgenic AD mouse models has subsequently been refocused to determine the mechanisms by which plaque clearance and reduced memory deficits are attained, and to establish safer therapeutic approaches that may reduce potentially harmful brain inflammation. The vigour of international research on immunotherapy for AD provides significant hope for a strong therapeutic lead for the escalating number of individuals who will develop this otherwise incurable condition. © 2007 Adis Data Information BV. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Woodhouse, A (Dr Adele Woodhouse)
Author:Dickson, TC (Professor Tracey Dickson)
Author:Vickers, JC (Professor James Vickers)
ID Code:46803
Year Published:2007
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2009-09-10
Downloads:0

Repository Staff Only: item control page