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Acute reactive and regenerative changes in mature cortical axons following injury


Dickson, TC and Chung, RS and McCormack, GH and Staal, JA and Vickers, JC, Acute reactive and regenerative changes in mature cortical axons following injury, Neuoreport, 18, (3) pp. 283-288. ISSN 0959-4965 (2007) [Refereed Article]

DOI: doi:10.1097/WNR.0b013e3280143cdb


Live-imaging brain slice techniques were utilized to study the acute changes in transected adult mammalian neocortical neuronal processes. Transected distal axons, but not axon segments directly emerging from the cell body or dendrites, undergo rapid morphological changes leading to attempted sprouting within hours after injury. The stereotypical response involved an initial retraction of the severed axon segments, followed by rapid stabilization. Subsequently, the cut-end underwent extensive swelling, forming large singular or multiple bulb-like structures. Two to three hours after transection, sprout-like protuberances emanated from the swollen bulbs. These axonal sprouts were highly dynamic, with many showing increased length over time and a capacity to change direction. These results indicate that damaged mature axons have an intrinsic capacity to react adaptively and attempt regeneration. © 2007 Lippincott Williams & Wilkins, Inc.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dickson, TC (Professor Tracey Dickson)
UTAS Author:Chung, RS (Associate Professor Roger Chung)
UTAS Author:McCormack, GH (Mr Graeme McCormack)
UTAS Author:Staal, JA (Dr Jerome Staal)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:45096
Year Published:2007
Web of Science® Times Cited:20
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2008-05-14

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