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Acute reactive and regenerative changes in mature cortical axons following injury

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posted on 2023-05-16, 19:24 authored by Tracey DicksonTracey Dickson, Chung, RS, Graeme McCormackGraeme McCormack, Staal, JA, James VickersJames Vickers
Live-imaging brain slice techniques were utilized to study the acute changes in transected adult mammalian neocortical neuronal processes. Transected distal axons, but not axon segments directly emerging from the cell body or dendrites, undergo rapid morphological changes leading to attempted sprouting within hours after injury. The stereotypical response involved an initial retraction of the severed axon segments, followed by rapid stabilization. Subsequently, the cut-end underwent extensive swelling, forming large singular or multiple bulb-like structures. Two to three hours after transection, sprout-like protuberances emanated from the swollen bulbs. These axonal sprouts were highly dynamic, with many showing increased length over time and a capacity to change direction. These results indicate that damaged mature axons have an intrinsic capacity to react adaptively and attempt regeneration. © 2007 Lippincott Williams & Wilkins, Inc.

History

Publication title

Neuoreport

Volume

18

Pagination

283-288

ISSN

0959-4965

Department/School

Menzies Institute for Medical Research

Publisher

LIPPINCOTT WILLIAMS & WILKINS

Place of publication

PHILADELPHIA, USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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