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Metallothioneins I and II: neuroprotective significance during CNS patholgoy


Stankovic, RK and Chung, RS and Penkowa, M, Metallothioneins I and II: neuroprotective significance during CNS patholgoy, The International Journal of Biochemistry & Cell Biology, 39, (3) pp. 484-489. ISSN 1357-2725 (2007) [Refereed Article]

Copyright Statement

2006 Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.biocel.2006.09.010


Metallothioneins (MTs) constitutes a superfamily of highly conserved, low molecular weight polypeptides, which are characterized by high contents of cysteine (sulphur) and metals. As intracellular metal-binding proteins they play a significant role in the regulation of essential metals. The major isoforms of the protein (MT-I and MT-II) are induced by numerous stimuli and pathogens but most importantly their induction by metals is closely linked to the physiological metabolism of zinc and protection from the toxic affects following heavy metal exposure. Although the preservation of their genetic expression across animal phyla suggests that MTs may play an important physiological role, MT-I, II knock out (KO) mice survive to adulthood. In both central and peripheral nervous tissues, MT-I, II have neuroprotective roles, which are also induced by exogenous MT-I and/or MT-II treatment. Hence, MT-I, II may provide neurotherapeutic targets offering protection against neuronal injury and degeneration.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Chung, RS (Associate Professor Roger Chung)
ID Code:45095
Year Published:2007
Web of Science® Times Cited:46
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2010-07-08

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