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Stability of cabergoline in fox baits in laboratory and field conditions

journal contribution
posted on 2023-05-16, 19:17 authored by Stuart McLeanStuart McLean, Brandon, S, Kirkwood, R
Cabergoline is a potent inhibitor of prolactin release and a potential fertility control agent for foxes. To understand how cabergoline could behave in baits deployed for fox control, we conducted laboratory and field trials to investigate the stability of cabergoline when (1) in solution, (2) injected into a bait (deep-fried liver and Foxoff®) and (3) exposed to a range of environmental conditions, including burial. Cabergoline, dissolved in a 1% acetic acid solution, and its carboxylic acid hydrolysis product can be assayed using high-performance liquid chromatography. When stored at 4°C and at room temperature, cabergoline in solution was stable for up to 36 days. When stored under cool (≤15°C), dry conditions, cabergoline (800 µg) in commercial Foxoff® and deep-fried ox-liver baits was stable for 28 and 7 days, respectively; stability was reduced by increases in temperature (tested up to 40°C) and humidity. Recovery of cabergoline from buried baits exposed to a range of field conditions decreased rapidly in the first week, but after 56 days remained detectable at levels of 6–22% of the injected amounts. This study has important implications for baiting campaigns that use cabergoline for fox control.

History

Publication title

Wildlife Research

Volume

34

Pagination

239-246

ISSN

1035-3712

Department/School

School of Pharmacy and Pharmacology

Publisher

CSIRO Publishing

Place of publication

Victoria, Australia

Rights statement

Copyright © 2007 CSIRO

Repository Status

  • Restricted

Socio-economic Objectives

Veterinary pharmaceutical products not elsewhere classified

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