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Cabergoline is a potent inhibitor of prolactin release and a potential fertility control agent for foxes. To understand how cabergoline could behave in baits deployed for fox control, we conducted laboratory and field trials to investigate the stability of cabergoline when (1) in solution, (2) injected into a bait (deep-fried liver and Foxoff®) and (3) exposed to a range of environmental conditions, including burial. Cabergoline, dissolved in a 1% acetic acid solution, and its carboxylic acid hydrolysis product can be assayed using high-performance liquid chromatography. When stored at 4°C and at room temperature, cabergoline in solution was stable for up to 36 days. When stored under cool (≤15°C), dry conditions, cabergoline (800 µg) in commercial Foxoff® and deep-fried ox-liver baits was stable for 28 and 7 days, respectively; stability was reduced by increases in temperature (tested up to 40°C) and humidity. Recovery of cabergoline from buried baits exposed to a range of field conditions decreased rapidly in the first week, but after 56 days remained detectable at levels of 6–22% of the injected amounts. This study has important implications for baiting campaigns that use cabergoline for fox control.

Item Type:	Refereed Article
Research Division:	Medical and Health Sciences
Research Group:	Pharmacology and Pharmaceutical Sciences
Research Field:	Pharmacology and Pharmaceutical Sciences not elsewhere classified
Objective Division:	Manufacturing
Objective Group:	Veterinary Pharmaceutical Products
Objective Field:	Veterinary Pharmaceutical Products not elsewhere classified
Author:	McLean, SR (Professor Stuart McLean)
Author:	Brandon, S (Mrs Susan Brandon)
ID Code:	44681
Year Published:	2007
Web of Science® Times Cited:	3
Deposited By:	Pharmacy
Deposited On:	2007-08-01
Last Modified:	2011-04-20
Downloads:	2 View Download Statistics