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Stability of cabergoline in fox baits in laboratory and field conditions
Citation
McLean, SR and Brandon, S and Kirkwood, R, Stability of cabergoline in fox baits in laboratory and field conditions, Wildlife Research, 34, (3) pp. 239-246. ISSN 1035-3712 (2007) [Refereed Article]
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Copyright Statement
Copyright © 2007 CSIRO
Official URL: http://www.csiro.au/
DOI: doi:10.1071/WR06094
Abstract
Cabergoline is a potent inhibitor of prolactin release and a potential fertility control agent for foxes. To understand how cabergoline could behave in baits deployed for fox control, we conducted laboratory and field trials to investigate the stability of cabergoline when (1) in solution, (2) injected into a bait (deep-fried liver and Foxoff®) and (3) exposed to a range of environmental conditions, including burial. Cabergoline, dissolved in a 1% acetic acid solution, and its carboxylic acid hydrolysis product can be assayed using high-performance liquid chromatography. When stored at 4°C and at room temperature, cabergoline in solution was stable for up to 36 days. When stored under cool (≤15°C), dry conditions, cabergoline (800 µg) in commercial Foxoff® and deep-fried ox-liver baits was stable for 28 and 7 days, respectively; stability was reduced by increases in temperature (tested up to 40°C) and humidity. Recovery of cabergoline from buried baits exposed to a range of field conditions decreased rapidly in the first week, but after 56 days remained detectable at levels of 6–22% of the injected amounts. This study has important implications for baiting campaigns that use cabergoline for fox control.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Pharmacology and pharmaceutical sciences not elsewhere classified |
Objective Division: | Manufacturing |
Objective Group: | Veterinary pharmaceutical products |
Objective Field: | Veterinary pharmaceutical products not elsewhere classified |
UTAS Author: | McLean, SR (Professor Stuart McLean) |
UTAS Author: | Brandon, S (Mrs Susan Brandon) |
ID Code: | 44681 |
Year Published: | 2007 |
Web of Science® Times Cited: | 3 |
Deposited By: | Pharmacy |
Deposited On: | 2007-08-01 |
Last Modified: | 2011-04-20 |
Downloads: | 2 View Download Statistics |
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