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A comparative study of functional assays for tissue factor pathway inhibitor using normal and clinical samples

Citation

Adams, MJ and Oostryck, R, A comparative study of functional assays for tissue factor pathway inhibitor using normal and clinical samples, Blood Coagulation and Fibrinolysis, 11, (4) pp. 327-333. ISSN 0957-5235 (2000) [Refereed Article]

DOI: doi:10.1097/00001721-200006000-00003

Abstract

Tissue factor pathway inhibitor (TFPI) is a Kunitz-type inhibitor that regulates the initiation of tissue factor-mediated coagulation. Recent reports in the literature have described variable results using different methodologies for TFPI measurement. In this study, we used one clotting and two amidolytic methodologies to assess TFPI functional levels. The study groups included normal healthy donors as well as patients with acute hepatitis, diabetes, coronary artery bypass graft operations, deep vein thrombosis, and prior to and during heparin therapy. The aims were to compare the results obtained in normal plasma using different assay systems, to compare TFPI levels in a range of clinical samples, including those previously not determined using a clotting methodology, and to report TFPI levels in patient groups previously not investigated. The results clearly demonstrate poor correlation between functional TFPI values using the different methodologies, highlighting the requirement for standardization. (C) 2000 Lippincott Williams and Wilkins.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Adams, MJ (Dr Murray Adams)
ID Code:43859
Year Published:2000
Web of Science® Times Cited:8
Deposited By:Health Sciences A
Deposited On:2007-03-27
Last Modified:2009-07-09
Downloads:0

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