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Long-term cognitive transitions, rates of cognitive change, and predictors of incident dementia in a population-based first-ever stroke cohort
Citation
Srikanth, V and Quinn, SJ and Donnan, G and Saling, M and Thrift, A, Long-term cognitive transitions, rates of cognitive change, and predictors of incident dementia in a population-based first-ever stroke cohort, Stroke, 37, (10) pp. 2479-2483. ISSN 0039-2499 (2006) [Refereed Article]
DOI: doi:10.1161/01.STR.0000239666.46828.d7
Abstract
BACKGROUND AND PURPOSE - There are few data on long-term cognitive outcomes after first-ever stroke. We aimed to study long-term cognitive transitions, rates of cognitive change, and factors associated with incident dementia and cognitive impairment-no dementia (CIND) 2 years after first-ever stroke. METHODS - A population-based cohort of incident first-ever stroke cases (n=99; mean age, 69.9 years) and an age- and sex-matched comparison group (nonstrokes, n=99) were followed up for 2 years by 3 serial examinations. Rates of cognitive change were compared by repeated-measures analyses. Factors associated with incident dementia and CIND at 2 years were determined by multinomial logistic regression. RESULTS - Significant stroke×time interactions were present for all cognitive domains, with stroke cases showing a greater rate of decline compared with nonstrokes. Stroke recurrence during follow-up was responsible for significantly greater global decline. Strokes with recurrence (P=0.02), age (P=0.004), and baseline cognitive impairment (P<0.001) were independently associated with incident dementia at 2 years. Strokes without recurrence (P=0.008), age (P=0.001), and baseline cognitive impairment (P<0.001) were independently associated with CIND at 2 years. CONCLUSIONS - Recurrent stroke contributes importantly to global cognitive decline after a first-ever stroke. Secondary stroke prevention will be important in ameliorating dementia related to stroke. Mechanisms underlying the progression of early cognitive impairment to dementia in stroke patients need further investigation. © 2006 American Heart Association, Inc.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Geriatrics and gerontology |
| Objective Division: | Health |
| Objective Group: | Specific population health (excl. Indigenous health) |
| Objective Field: | Health related to ageing |
| UTAS Author: | Srikanth, V (Dr Velandai Srikanth) |
| UTAS Author: | Quinn, SJ (Dr Stephen Quinn) |
| ID Code: | 43278 |
| Year Published: | 2006 |
| Web of Science® Times Cited: | 68 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2006-08-01 |
| Last Modified: | 2009-10-06 |
| Downloads: | 0 |
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