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Which is the safest NSAID for patients at elevated cardiovascular risk?


Bereznicki, LRE and Jackson, SL and Peterson, GM, Which is the safest NSAID for patients at elevated cardiovascular risk?, Australian Pharmacist, 25, (11) pp. 853. ISSN 0728-4632 (2006) [Professional, Non Refereed Article]

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The issue of the cardiovascular risk associated with non-steroidal antiinflammatory drugs (NSAIDs) intensified recenty with the release of a systematic review of observational studies questioning the safety of diclofenac, a non-selective NSAID. In fact, this review demonstrated an increased cardiovascular risk for rofecoxib, diclofenac, meloxicam and indomethacin; a neutral effect was shown with celecoxib, naproxen and ibuprofen (although the lower bound of the 95% confidence interval for the latter approached, which is less than reassuring). Observational studies are limited in that they are generally based on the prescription of drugs via health care providers; this makes it difficult to discern what dosages have actually been taken, and whether subjects have used over-the-counter NSAIDs or concomitant low-dose aspirin.

Item Details

Item Type:Professional, Non Refereed Article
Keywords:cardiovascular risk, non-steroidal anti-inflammatory drugs, NSAIDs
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Bereznicki, LRE (Professor Luke Bereznicki)
UTAS Author:Jackson, SL (Dr Shane Jackson)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:43208
Year Published:2006
Deposited By:Pharmacy
Deposited On:2006-08-01
Last Modified:2012-10-17

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