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The regioselective synthesis of aryl pyrroles
journal contribution
posted on 2023-05-16, 18:49 authored by Jason SmithJason Smith, Ng, M, White, JPyrrole is a unique aromatic molecule as it can readily undergo substitution at all five positions but obtaining the desired regioisomer can prove difficult to control. We now report our results on the regioselective arylation of pyrrole, utilizing selective halogenation and the Suzuki-Miyaura reaction to prepare C4-, C5- and C3-aryl derivatives. We have applied this methodology to the synthesis of lamellarin O dimethyl ether, an intermediate in the synthesis of lukinol A. © The Royal Society of Chemistry 2006.
History
Publication title
Organic and Biomolecular ChemistryVolume
4Issue
12Pagination
2477-2482ISSN
1477-0520Department/School
School of Natural SciencesPublisher
Royal Society of ChemistryPlace of publication
Cambridge UKRepository Status
- Restricted