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The regioselective synthesis of aryl pyrroles


Smith, JA and Ng, M and White, J, The regioselective synthesis of aryl pyrroles, Organic and Biomolecular Chemistry, 4, (12) pp. 2477-2482. ISSN 1477-0520 (2006) [Refereed Article]

DOI: doi:10.1039/b604692d


Pyrrole is a unique aromatic molecule as it can readily undergo substitution at all five positions but obtaining the desired regioisomer can prove difficult to control. We now report our results on the regioselective arylation of pyrrole, utilizing selective halogenation and the Suzuki-Miyaura reaction to prepare C4-, C5- and C3-aryl derivatives. We have applied this methodology to the synthesis of lamellarin O dimethyl ether, an intermediate in the synthesis of lukinol A. © The Royal Society of Chemistry 2006.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Organic chemistry
Research Field:Organic chemical synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Smith, JA (Associate Professor Jason Smith)
UTAS Author:Ng, M (Miss Sarah Ng)
ID Code:43149
Year Published:2006
Web of Science® Times Cited:39
Deposited By:Chemistry
Deposited On:2006-08-01
Last Modified:2007-04-03

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