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Comprehensive two-dimensional liquid chromatography
Citation
Shellie, RA and Haddad, PR, Comprehensive two-dimensional liquid chromatography, Analytical and Bioanalytical Chemistry, 386, (3) pp. 405-415. ISSN 1618-2642 (2006) [Refereed Article]
DOI: doi:10.1007/s00216-006-0516-0
Abstract
Having nearly exhausted the possibilities for generating peak capacity through improvements in column technology, chromatographers are increasingly looking to alternative ways of maximising chromatographic separation. In recent years there has been increasing activity in the field of comprehensive multidimensional separations to meet analysis demands. Comprehensive two-dimensional liquid chromatography (LC×LC) approaches offer high peak capacity which leads to significantly improved analytical performance over single-column liquid chromatography. There are several closely related avenues available for achieving an LC×LC separation and this review pays special attention to the different valve-based interfaces that have been used to comprehensively couple the first and second dimension columns in LC×LC systems. A brief discussion of column choices for selected applications and the conditions employed is also presented. © Springer-Verlag 2006.
Item Details
Item Type: | Refereed Article |
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Research Division: | Chemical Sciences |
Research Group: | Analytical Chemistry |
Research Field: | Separation Science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding Knowledge |
Objective Field: | Expanding Knowledge in the Chemical Sciences |
UTAS Author: | Shellie, RA (Associate Professor Robert Shellie) |
UTAS Author: | Haddad, PR (Professor Paul Haddad) |
ID Code: | 43044 |
Year Published: | 2006 |
Web of Science® Times Cited: | 56 |
Deposited By: | Chemistry |
Deposited On: | 2006-08-01 |
Last Modified: | 2009-09-22 |
Downloads: | 0 |
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