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Mapping of the Plasmodium chabaudi Resistance Locus Char2
journal contribution
posted on 2023-05-16, 18:41 authored by Lin, E, Pappenfuss, T, Tan, RB, Senyschyn, D, Bahlo, M, Speed, TP, Simon James FooteSimon James FooteAnimals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
History
Publication title
Infection and ImmunityVolume
74Issue
10Pagination
5814-5819ISSN
0019-9567Department/School
Menzies Institute for Medical ResearchPublisher
American Society for MicrobiologyPlace of publication
United StatesRepository Status
- Restricted