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Mapping of the Plasmodium chabaudi Resistance Locus Char2

Citation

Lin, E and Pappenfuss, T and Tan, RB and Senyschyn, D and Bahlo, M and Speed, TP and Foote, SJ, Mapping of the Plasmodium chabaudi Resistance Locus Char2, Infection and Immunity, 74, (10) pp. 5814-5819. ISSN 0019-9567 (2006) [Refereed Article]

DOI: doi:10.1128/IAI.01690-05

Abstract

Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Medical Genetics (excl. Cancer Genetics)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Inherited Diseases (incl. Gene Therapy)
Author:Foote, SJ (Professor Simon Foote)
ID Code:42787
Year Published:2006
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2006-08-01
Last Modified:2007-04-04
Downloads:0

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