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Muscle metabolism and control of capillary blood flow: insulin and exercise

Citation

Rattigan, S and Bradley, EA and Richards, SM and Clark, MG, Muscle metabolism and control of capillary blood flow: insulin and exercise, Essays in Biochemistry, 42, (1) pp. 133-144. ISSN 0071-1365 (2006) [Refereed Article]

DOI: doi:10.1042/bse0420133

Abstract

The evidence that muscle metabolism is determined by available capillary surface area is examined. From newly developed methods it is clear that exercise and insulin mediate capillary recruitment as part of their actions in vivo. In all insulin-resistant states examined thus far, insulin-mediated capillary recruitment is impaired with little or no change to the exercise response. Control mechanisms for capillary recruitment for exercise and insulin are considered, and the failure of the microvasculature to respond to insulin is examined for possible mechanisms that might account for impaired vascular responses to insulin in insulin resistance. © 2006 The Biochemical Society.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Rattigan, S (Professor Stephen Rattigan)
Author:Bradley, EA (Miss Eloise Bradley)
Author:Richards, SM (Dr Stephen Richards)
Author:Clark, MG (Professor Michael Clark)
ID Code:41929
Year Published:2006
Web of Science® Times Cited:6
Deposited By:Biochemistry
Deposited On:2006-08-01
Last Modified:2012-03-05
Downloads:0

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