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Factors influencing the hemodynamic and metabolic effects of insulin in muscle
Citation
Rattigan, S and Zhang, L and Mahajan, H and Kolka, CM and Richards, SM and Clark, MG, Factors influencing the hemodynamic and metabolic effects of insulin in muscle, Current Diabetes Reviews, 2, (1) pp. 61-70. ISSN 1573-3998 (2006) [Refereed Article]
DOI: doi:10.2174/157339906775473653
Abstract
Insulin mediates its own access and that of glucose to muscle by capillary recruitment and an increase in bulk blood flow. In addition, insulin resistance of muscle may result in part from an impaired hemodynamic action of insulin. The present review examines some of the factors that influence the effects of insulin both at the level of hemodynamics and metabolism in muscle. Factors include fatty acids, the inflammatory cytoldne TNFα, vasodilators that relax the blood vessels and increase bulk flow, and elevated blood pressure that may be mediated by endothelin, a potent locally released vasoconstrictor, or other vasoconstrictor influences. © 2006 Bentham Science Publishers Ltd.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Endocrinology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Diabetes |
| Author: | Rattigan, S (Professor Stephen Rattigan) |
| Author: | Zhang, L (Mr Lejun Zhang) |
| Author: | Mahajan, H (Dr Hema Mahajan) |
| Author: | Kolka, CM (Miss Cathryn Kolka) |
| Author: | Richards, SM (Dr Stephen Richards) |
| Author: | Clark, MG (Professor Michael Clark) |
| ID Code: | 41921 |
| Year Published: | 2006 |
| Deposited By: | Biochemistry |
| Deposited On: | 2006-08-01 |
| Last Modified: | 2011-09-30 |
| Downloads: | 0 |
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