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Factors influencing the hemodynamic and metabolic effects of insulin in muscle

journal contribution
posted on 2023-05-16, 18:29 authored by Stephen RattiganStephen Rattigan, Lejun ZhangLejun Zhang, Mahajan, H, Kolka, CM, Stephen RichardsStephen Richards, Michael ClarkMichael Clark
Insulin mediates its own access and that of glucose to muscle by capillary recruitment and an increase in bulk blood flow. In addition, insulin resistance of muscle may result in part from an impaired hemodynamic action of insulin. The present review examines some of the factors that influence the effects of insulin both at the level of hemodynamics and metabolism in muscle. Factors include fatty acids, the inflammatory cytoldne TNFα, vasodilators that relax the blood vessels and increase bulk flow, and elevated blood pressure that may be mediated by endothelin, a potent locally released vasoconstrictor, or other vasoconstrictor influences. © 2006 Bentham Science Publishers Ltd.

History

Publication title

Current Diabetes Reviews

Pagination

61-70

ISSN

1573-3998

Department/School

Tasmanian School of Medicine

Publisher

Bentham Science Publishers

Place of publication

Netherlands

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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