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Factors influencing the hemodynamic and metabolic effects of insulin in muscle


Rattigan, S and Zhang, L and Mahajan, H and Kolka, CM and Richards, SM and Clark, MG, Factors influencing the hemodynamic and metabolic effects of insulin in muscle, Current Diabetes Reviews, 2, (1) pp. 61-70. ISSN 1573-3998 (2006) [Refereed Article]

DOI: doi:10.2174/157339906775473653


Insulin mediates its own access and that of glucose to muscle by capillary recruitment and an increase in bulk blood flow. In addition, insulin resistance of muscle may result in part from an impaired hemodynamic action of insulin. The present review examines some of the factors that influence the effects of insulin both at the level of hemodynamics and metabolism in muscle. Factors include fatty acids, the inflammatory cytoldne TNFα, vasodilators that relax the blood vessels and increase bulk flow, and elevated blood pressure that may be mediated by endothelin, a potent locally released vasoconstrictor, or other vasoconstrictor influences. © 2006 Bentham Science Publishers Ltd.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Rattigan, S (Professor Stephen Rattigan)
UTAS Author:Zhang, L (Dr Lejun Zhang)
UTAS Author:Mahajan, H (Dr Hema Mahajan)
UTAS Author:Kolka, CM (Miss Cathryn Kolka)
UTAS Author:Richards, SM (Dr Stephen Richards)
UTAS Author:Clark, MG (Professor Michael Clark)
ID Code:41921
Year Published:2006
Deposited By:Biochemistry
Deposited On:2006-08-01
Last Modified:2011-09-30

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