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Correlates of knee pain in younger subjects


Zhai, G and Cicuttini, F and Ding, C and Scott, F and Garnero, P and Jones, G, Correlates of knee pain in younger subjects, Clinical Rheumatology, 26, (1) pp. 75-80. ISSN 0770-3198 (2006) [Refereed Article]

DOI: doi:10.1007/s10067-006-0248-8


The aim of this study was to describe clinical, structural and biochemical factors associated with knee pain in younger subjects. A cross-sectional convenience sample of 371 male and female subjects (mean age, 45 years, range 26-61) was studied. Knee pain was assessed by questionnaire. Chondral defects, cartilage volume, and bone area of the right knee were determined using T1-weighted fat saturation magnetic resonance imaging (MRI). X-ray was performed on the same knee for the assessment of radiographic features of osteoarthritis. The urinary C-terminal cross-linking telopeptide of type II collagen (CTX-II) was measured by enzyme-linked immunosorbent assay (ELISA). Height and weight were measured by standard protocols and body mass index (BMI) was calculated. The prevalence of knee pain was 35% in this sample. Chondral defect scores (particularly femoral and patellar but not tibial) were significantly associated with knee pain in a dose-response fashion (all p<0.01). Cartilage volume and bone area were not associated with knee pain in multivariate analysis in this sample. Urinary CTX-II was higher in subjects with knee pain (p = 0.04), but this became nonsignificant after adjustment for BMI and osteophytes (both of which were significant) suggesting potential mechanisms of effect. In conclusion, knee pain is significantly associated with non-full thickness chondral defects (particularly femoral and patellar), osteophytes, CTX-II, and obesity but not other factors. MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhai, G (Dr Guangju Zhai)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Scott, F (Dr Fiona Scott)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:41803
Year Published:2006
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2006-08-01
Last Modified:2010-06-08

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