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Correlates of knee pain in younger subjects
Citation
Zhai, G and Cicuttini, F and Ding, C and Scott, F and Garnero, P and Jones, G, Correlates of knee pain in younger subjects, Clinical Rheumatology, 26, (1) pp. 75-80. ISSN 0770-3198 (2006) [Refereed Article]
DOI: doi:10.1007/s10067-006-0248-8
Abstract
The aim of this study was to describe clinical, structural and biochemical factors associated with knee pain in younger subjects. A cross-sectional convenience sample of 371 male and female subjects (mean age, 45 years, range 26-61) was studied. Knee pain was assessed by questionnaire. Chondral defects, cartilage volume, and bone area of the right knee were determined using T1-weighted fat saturation magnetic resonance imaging (MRI). X-ray was performed on the same knee for the assessment of radiographic features of osteoarthritis. The urinary C-terminal cross-linking telopeptide of type II collagen (CTX-II) was measured by enzyme-linked immunosorbent assay (ELISA). Height and weight were measured by standard protocols and body mass index (BMI) was calculated. The prevalence of knee pain was 35% in this sample. Chondral defect scores (particularly femoral and patellar but not tibial) were significantly associated with knee pain in a dose-response fashion (all p<0.01). Cartilage volume and bone area were not associated with knee pain in multivariate analysis in this sample. Urinary CTX-II was higher in subjects with knee pain (p = 0.04), but this became nonsignificant after adjustment for BMI and osteophytes (both of which were significant) suggesting potential mechanisms of effect. In conclusion, knee pain is significantly associated with non-full thickness chondral defects (particularly femoral and patellar), osteophytes, CTX-II, and obesity but not other factors. MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Zhai, G (Dr Guangju Zhai) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| UTAS Author: | Scott, F (Dr Fiona Scott) |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| ID Code: | 41803 |
| Year Published: | 2006 |
| Web of Science® Times Cited: | 28 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2006-08-01 |
| Last Modified: | 2010-06-08 |
| Downloads: | 0 |
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