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Natural History of Knee Cartilage Defects and Factors Affecting Change
Citation
Ding, C and Cicuttini, F and Scott, F and Cooley, HM and Boon, CM and Jones, G, Natural History of Knee Cartilage Defects and Factors Affecting Change, Archives of Internal Medicine, 166, (6) pp. 651-658. ISSN 0003-9926 (2006) [Refereed Article]
DOI: doi:10.1001/archinte.166.6.651
Abstract
Background: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history. Methods: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later. Results: Thirty-three percent of the subjects had a worsening (≥1-point increase) and 37% of the subjects had an improvement (≥1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment). Conclusions: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects. ©2006 American Medical Association. All rights reserved.
Item Details
Item Type: | Refereed Article |
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Research Division: | Health Sciences |
Research Group: | Epidemiology |
Research Field: | Epidemiology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
UTAS Author: | Scott, F (Dr Fiona Scott) |
UTAS Author: | Cooley, HM (Dr Helen Cooley) |
UTAS Author: | Boon, CM (Mrs Catrina Boon) |
UTAS Author: | Jones, G (Professor Graeme Jones) |
ID Code: | 41788 |
Year Published: | 2006 |
Web of Science® Times Cited: | 129 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2006-08-01 |
Last Modified: | 2007-10-11 |
Downloads: | 0 |
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