Background: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history. Methods: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later. Results: Thirty-three percent of the subjects had a worsening (≥1-point increase) and 37% of the subjects had an improvement (≥1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment). Conclusions: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects. ©2006 American Medical Association. All rights reserved.

Item Type:	Refereed Article
Research Division:	Medical and Health Sciences
Research Group:	Public Health and Health Services
Research Field:	Epidemiology
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Skeletal System and Disorders (incl. Arthritis)
Author:	Ding, C (Professor Chang-Hai Ding)
Author:	Scott, F (Dr Fiona Scott)
Author:	Cooley, HM (Dr Helen Cooley)
Author:	Boon, CM (Mrs Catrina Boon)
Author:	Jones, G (Professor Graeme Jones)
ID Code:	41788
Year Published:	2006
Web of Science® Times Cited:	106
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2006-08-01
Last Modified:	2007-10-11
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