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Encasement of bedding does not improve asthma in atopic adult asthmatics

Citation

Dharmage, S and Walters, EH and Thien, F and Bailey, M and Raven, J and Wharton, C and Rolland, J and Light, L and Freezer, N and Abramson, M, Encasement of bedding does not improve asthma in atopic adult asthmatics, International Archives of Allergy and Immunology, 139, (2) pp. 132-138. ISSN 1018-2438 (2006) [Refereed Article]

DOI: doi:10.1159/000090388

Abstract

Aim: We evaluated the impact of impermeable bed covers on asthma in asthmatics with clinically relevant house dust mite (HDM) sensitization. Methods: The study included 32 HDM-sensitized asthmatics in whom HDM allergy was considered as a significant factor in their asthma. They were randomized into either an intervention group whose bedding was encased with impermeable covers, or a control group who received cotton covers. Before and 3 and 6 months after encasement, dust samples were collected from the bedding and assayed for Der p 1. Clinical outcomes included quality of life, lung function, bronchial reactivity to methacholine, symptoms, medications and peak flow rates. Results: Baseline Der p 1 levels in both the active and the placebo groups were comparable and high (19.2 vs 18.9 μg/g of dust). There was a significant reduction in Der p 1 levels in the active group after 6 months, but not in the placebo group (7.3 vs 21.9 μg/g of dust). Quality of life improved significantly in both the intervention and control groups, but there was no significant difference in the improvements between the groups. There was no significant change in lung function, symptoms, and requirements for medications. Conclusions: Encasement of bedding significantly reduced the Der p 1 levels. However, this was not sufficient to produce worthwhile clinical improvement in those in whom dust mite avoidance might well have been recommended as part of their clinical management. Copyright © 2006 S. Karger AG.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Walters, EH (Professor Haydn Walters)
ID Code:41718
Year Published:2006
Web of Science® Times Cited:11
Deposited By:Medicine (Discipline)
Deposited On:2006-08-01
Last Modified:2007-03-21
Downloads:0

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