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Complex genetics of complex traits: the case of primary open-angle glaucoma
Citation
Hewitt, AW and Craig, JE and Mackey, DA, Complex genetics of complex traits: the case of primary open-angle glaucoma, Clinical and Experimental Ophthalmology, 34, (5) pp. 472-484. ISSN 1442-6404 (2006) [Refereed Article]
DOI: doi:10.1111/j.1442-9071.2006.1268.x
Abstract
Glaucoma, which is a complex heterogeneous disease, presents an ideal case for genetic investigation. Primary open-angle glaucoma (POAG) is the commonest subtype and will be the focus of this review. When detected early, POAG is amenable to therapeutic intervention. Unfortunately, current population-based clinical screening lacks efficacy. If individuals with a genetic predisposition for developing POAG can be identified, then efficient and cost-effective population-based screening programs could be designed. Although considerable inroads have been made in understanding the natural history of POAG caused by mutations in the myocilin and optineurin genes, other POAG genes accounting for most cases remain to be identified. This review explores the genetic mechanisms that have been unequivocally linked to the glaucomatous process and then discusses potential avenues for future breakthroughs.
Item Details
Item Type: | Refereed Article |
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Research Division: | Medical and Health Sciences |
Research Group: | Ophthalmology and Optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Hearing, Vision, Speech and Their Disorders |
UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
UTAS Author: | Mackey, DA (Professor David Mackey) |
ID Code: | 41591 |
Year Published: | 2006 |
Web of Science® Times Cited: | 57 |
Deposited By: | Medicine |
Deposited On: | 2006-08-01 |
Last Modified: | 2014-10-08 |
Downloads: | 0 |
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