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Treatment with the thiazolidinedione (BRL 49653) decreases insulin resistance in obese Zucker hindlimb

Citation

Eldershaw, TPD and Rattigan, S and Cawthorne, MA and Buckingham, RE and Colquhoun, EQ and Clark, MG, Treatment with the thiazolidinedione (BRL 49653) decreases insulin resistance in obese Zucker hindlimb, Hormone and Metabolic Research, 27, (4) pp. 169-172. ISSN 0018-5043 (1995) [Refereed Article]

DOI: doi:10.1055/s-2007-979932

Abstract

Hindlimbs of mature age obese fa/fa Zucker rats were perfused and found to be markedly insulin-resistant when compared to the hindlimbs of age-matched lean Fa/? animals. Hindlimb analysis also showed a greater content of fat and a lower content of muscle in the obese. Treatment of the obese animals for 7 days with the thiazolidinedione, BRL 49653 (3 μmol/kg/day) significantly decreased the insulin resistance of the hindlimb and significantly increased the rate of weight gain in the whole rat. However, the decreased insulin resistance due to BRL 49653 could not be accounted for by an increase in the proportion of hindlimb muscle to fat or by an increase in the hindlimb muscle mass perfused.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Eldershaw, TPD (Mr Tristram Eldershaw)
Author:Rattigan, S (Professor Stephen Rattigan)
Author:Colquhoun, EQ (Dr Eric Colquhoun)
Author:Clark, MG (Professor Michael Clark)
ID Code:4159
Year Published:1995
Web of Science® Times Cited:28
Deposited By:Biochemistry
Deposited On:1995-08-01
Last Modified:2011-08-22
Downloads:0

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