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The Mechanisms of Neuropathic Pain; an Overview for Psychiatrists


Pridmore, S and Pasha, I and Kahn, U, The Mechanisms of Neuropathic Pain; an Overview for Psychiatrists, German Journal of Psychiatry, 5, (1) pp. 35-39. ISSN 1433-1055 (2002) [Refereed Article]


Objective: To present an overview of the mechanisms of neuropathic pain. Method: An extensive review of the scientific literature. Results: Neuroplastic changes are described under the headings of: ectopic discharge, sensitization of sensory terminals, cross-excitation, neurotransmitter change, coupling between the sympathetic and sensory nervous systems, spinal cord reorganization, spinal cord increased excitability, spinal cord decreased inhibition, supraspinal influences. Conclusions: These mechanisms increase our understanding of the patient with neuropathic pain and open the door for therapeutic advances in this field. They also extend our understanding of the nature of the nervous system more generally, and may provide pathophysiologic models of psychiatric disorders.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Pridmore, S (Professor Saxby Pridmore)
ID Code:41466
Year Published:2002
Deposited By:Psychiatry
Deposited On:2007-01-15
Last Modified:2007-01-15

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