eCite Digital Repository

The risks of warfarin use in the elderly


Bereznicki, LR and Peterson, GM and Jackson, SL and Jeffrey, EC, The risks of warfarin use in the elderly, Expert Opinion on Drug Safety, 5, (3) pp. 417-431. ISSN 1474-0338 (2006) [Refereed Article]

Restricted - Request a copy

Copyright Statement

Copyright 2006 Informa Plc

Official URL:

DOI: doi:10.1517/14740338.5.3.417


The use of warfarin in the elderly, particularly for stroke prevention in chronic atrial fibrillation, is steadily increasing. Although the benefits of warfarin are greatest in the elderly, so are the risk of adverse outcomes and the difficulties of anticoagulant management. Clinical systems need to improve to counter this therapeutic dilemma, as warfarin is likely to remain the only widely available oral anticoagulant for the foreseeable future. Aspects that require attention are: the careful selection of patients in whom treatment with warfarin is appropriate; initiating therapy in a low dose (e.g., 2.5 5 mg/day); thorough education of patients and carers; close monitoring, especially with any change in the patient's regular drug therapy; involving patients more in the management of their warfarin therapy (self-monitoring/management in suitable patients); and ongoing review of the appropriateness of therapy as circumstances change.

Item Details

Item Type:Refereed Article
Keywords:anticoagulation, elderly, warfarin
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Bereznicki, LR (Professor Luke Bereznicki)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Jackson, SL (Dr Shane Jackson)
UTAS Author:Jeffrey, EC (Mrs Ella van Tienen)
ID Code:40204
Year Published:2006
Web of Science® Times Cited:12
Deposited By:Pharmacy
Deposited On:2006-08-01
Last Modified:2015-07-31
Downloads:1 View Download Statistics

Repository Staff Only: item control page