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Effects of capsaicin, dihydrocapsaicin and curcumin on copper-induced oxidation of human serum lipids


Ahuja, KDK and Kunde, DA and Ball, MJ and Geraghty, DP, Effects of capsaicin, dihydrocapsaicin and curcumin on copper-induced oxidation of human serum lipids, Journal of Agricultural and Food Chemistry, 54, (17) pp. 6436-6439. ISSN 0021-8561 (2006) [Refereed Article]

DOI: doi:10.1021/jf061331j


The oxidation of low-density lipoprotein (LDL) is believed to be the initiating factor for the development and progression of atherosclerosis. The active ingredients of spices such as chili and turmeric (capsaicin and curcumin, respectively) have been shown to reduce the susceptibility of LDL to oxidation. One of the techniques used to study the oxidation of LDL is to isolate LDL and subject it to metal-induced (copper or iron) oxidation. However, whole serum may represent a closer situation to in vivo conditions than using isolated LDL. We investigated the effects of different concentrations (0.1-3 μM) of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of serum lipoproteins. The lag time (before initiation of oxidation) and rate of oxidation (slope of propagation phase) were calculated. The lag time increased, and the rate of oxidation decreased with increasing concentrations of the tested antioxidants (p < 0.05). A 50% increase in lag time (from control) was observed at concentrations between 0.5 and 0.7 μM for capsaicin, dihydrocapsaicin, and curcumin. This study shows that oxidation of serum lipids is reduced by capsaicinoids and curcumin in a concentration-dependent manner. © 2006 American Chemical Society.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - lipids
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Ahuja, KDK (Dr Kiran Ahuja)
UTAS Author:Kunde, DA (Dr Dale Kunde)
UTAS Author:Ball, MJ (Professor Madeleine Ball)
UTAS Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:39780
Year Published:2006
Web of Science® Times Cited:43
Deposited By:Health Sciences A
Deposited On:2006-08-01
Last Modified:2008-06-18

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