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Baseline serum lipids and renal function in chronic kidney disease patients entering the LORD trial

Citation

Fassett, RG and Ball, MJ and Robertson, IK and Geraghty, DP and Coombes, JS, Baseline serum lipids and renal function in chronic kidney disease patients entering the LORD trial, International Journal of Clinical Pharmacology and Therapeutics, 44, (11) pp. 580-588. ISSN 0946-1965 (2006) [Refereed Article]


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Copyright Statement

Copyright 2007 Dustri-Verlag

Official URL: http://www.dustri.com/nc/journals-in-english/mag/i...

Abstract

OBJECTIVE: Previous studies investigating associations between serum lipids and renal disease have generally not taken into account dietary intake or physical activity both known to influence circulating lipids. Furthermore, inclusion of patients on HMG-CoA reductase inhibitors may also have influenced findings due to the pleiotropic effect of this medication. Therefore, the aim of this study is to determine the relationships between serum lipids and renal function in a group of patients not taking lipid-lowering medication and taking into account dietary intake and physical activity. METHODS: Data from 100 patients enrolled in the Lipid Lowering and Onset of Renal Disease (LORD) trial were used in this study. Patients were included with serum creatinine > 120 micromol/l, and excluded if they were taking lipid-lowering medication. Unadjusted and adjusted relationships were determined between fasting serum lipid concentrations (total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol/HDL ratio) and measures of renal function (estimated glomerular filtration rate (eGFR), creatinine clearance and serum creatinine) and urinary protein excretion. RESULTS: Significant (p < 0.05) negative unadjusted relationships were found between lipids (total cholesterol, LDL and HDL cholesterol) and serum creatinine. In support of these findings, logarithmically-transformed lipids (total cholesterol, LDL and HDL cholesterol) were significantly associated with eGFR and creatinine clearance although the effects were of a smaller magnitude. Adjustment for dietary saturated fat intake and physical activity did not substantially change these effects. CONCLUSION: These data do not support the premise that lipids are associated with renal dysfunction in patients with normocholesterolemia.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Nephrology and Urology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Urogenital System and Disorders
Author:Ball, MJ (Professor Madeleine Ball)
Author:Robertson, IK (Dr Iain Robertson)
Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:39439
Year Published:2006
Web of Science® Times Cited:6
Deposited By:Health Sciences A
Deposited On:2006-08-01
Last Modified:2011-07-21
Downloads:0

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