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The Dynamics and Associations of Airway Neutrophilia Post Lung Transplantation

Citation

Zheng, L and Whitford, HM and Orsida, B and Levvey, BJ and Bailey, M and Walters, EH and Williams, TJ and Kotsimbos, T and Snell, GI, The Dynamics and Associations of Airway Neutrophilia Post Lung Transplantation, American Journal of Transplantation, 6, (3) pp. 599-608. ISSN 1600-6135 (2006) [Refereed Article]

DOI: doi:10.1111/j.1600-6143.2005.01222.x

Abstract

Bronchoalveolar lavage (BAL) neutrophilia has been repeatedly observed in lung transplant recipients with established bronchiolitis obliterans syndrome (BOS). Little is known of the fluctuations in BAL and airway neutrophilic inflammation post-transplant. This prospective longitudinal study aimed to evaluate the dynamic changes of lung allograft neutrophils with time, immunosuppression, infection and BOS. A total of 28, initially healthy, BOS 0, lung transplant recipients underwent 134 bronchoscopic assessments, including BAL and endobronchial biopsies (EBB) (with immunohistochemistry) over 3-year follow up. Subsequently, 21 developed BOS 0p and 16 ultimately BOS. Compared to controls, there was early and persistent BAL neutrophilia (p < 0.05), contrasting with an initially normal EBB that shows a progressive increased airway wall neutrophil infiltrate. BAL neutrophilia (but not airway wall neutrophilia) was most striking when there was concomitant bronchopulmonary infection, particularly in the patients with BOS. Univariate and multivariate analyses suggested that BAL neutrophilia was linked to markers of infection while EBB neutrophilia was linked with coexistent inflammation with macrophages and lymphocytes. In conclusion: (i) BAL neutrophilia is predominantly associated with infection; (ii) Airway wall neutrophilia (as monitored by EBB) increases with time post-transplant and is not associated with infection; (iii) By itself, BOS is not the major contributor to BAL and EBB neutrophilia. © 2006 The American Society of Transplantation and the American Society of Transplant Surgeons.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Walters, EH (Professor Haydn Walters)
ID Code:38989
Year Published:2006
Web of Science® Times Cited:24
Deposited By:Medicine (Discipline)
Deposited On:2006-08-01
Last Modified:2007-05-17
Downloads:0

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