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Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis


Cicuttini, F and Hankin, J and Jones, G and Wluka, A, Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis, Osteoarthritis and Cartilage, 13, (8) pp. 722-727. ISSN 1063-4584 (2005) [Refereed Article]

DOI: doi:10.1016/j.joca.2005.04.009


Objective: Although the current recommendation is to measure radiographic joint space width (JSW) to assess structural change in osteoarthritis (OA), there is increasing interest in direct measurement of cartilage volume from magnetic resonance imaging (MRI). We performed a longitudinal study to compare change in both JSW and articular cartilage volume in subjects with symptomatic knee OA. Methods: JSW was measured in 28 subjects with knee OA (57% females, mean age 62.8 ± 9.8 years) who had standing radiographs in full extension, where both radiographs had satisfactory alignment. Each subject had femoral, tibial and combined femoral and tibial cartilage volumes determined from T1-weighted fat saturated sagittal knee MRI. All subjects had a repeat of the knee radiograph and MRI 1.96 ± 0.4 years later. Results: At baseline there was a moderate, but statistically significant, correlation between JSW and femoral and tibial cartilage volumes in the medial tibiofemoral joint, which was strengthened by adjusting for medial tibial bone size (R = 0.58-0.66, P = 0.001). Although we observed a reduction in JSW and femoral and tibial cartilage volumes over the study period, there was no significant association between reduction in JSW and cartilage volume (R < 0.13). There was a trend towards a significant association between change in medial tibiofemoral cartilage volume and joint replacement at 4 years (OR = 9.0, P = 0.07) but not change in medial tibiofemoral JSW (OR = 1.1, P = 0.92). Conclusions: Although there was a modest correlation between cartilage volume and JSW in the medial tibiofemoral compartment, there was no correlation between longitudinal change in these measures. Change in cartilage volume appears to be a better predictor of joint replacement. Further work in larger samples over a longer period of time will be needed to confirm these findings. © 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:38640
Year Published:2005
Web of Science® Times Cited:73
Deposited By:Menzies Institute for Medical Research
Deposited On:2005-08-01
Last Modified:2006-04-08

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