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Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II breakdown

Citation

Ding, C and Garnero, P and Cicuttini, F and Scott, F and Cooley, HM and Jones, G, Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II breakdown, Osteoarthritis and Cartilage, 13, (3) pp. 198-205. ISSN 1063-4584 (2005) [Refereed Article]

DOI: doi:10.1016/j.joca.2004.11.007

Abstract

Objective: To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults. Methods: A cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61) was studied. Knee cartilage defect score (0-4) and prevalence (a defect score of ≥2), cartilage volume, and bone surface area were determined using T1-weighted fat saturation MRI. Urinary levels of C-terminal crosslinking telopeptide of type II collagen (U-CTX-II) were measured by enzyme-linked immunosorbent assay. Height, weight and ROA were measured by standard protocols. Results: In multivariate analysis, the severity and prevalence of knee cartilage defects were significantly and independently associated with tibiofemoral osteophytes (regression coefficient (β): +0.86 to +1.31/unit, odds ratio (OR): 2.97-3.68/unit, all P < 0.05 with the exception of OR in lateral tibiofemoral compartment) and tibial bone area (β: +0.11 to +0.25/cm2; OR: 1.33-1.58/ cm2, all P < 0.01). Knee cartilage defects were inconsistently associated with joint space narrowing after adjustment for osteophytes but consistently with knee cartilage volume (β: -0.27 to -0.70/ml; OR: 0.16-0.56/ml, all P < 0.01 except for OR at lateral tibial cartilage site P = 0.06). Lastly, knee cartilage defect severity was significantly associated with U-CTX-II (Partial r = +0.18, P < 0.001 for total cartilage defect score). Conclusion: Osteophytes and increas ing knee bone size may be causally related to knee cartilage defects. Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA. © 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Scott, F (Dr Fiona Scott)
Author:Cooley, HM (Dr Helen Cooley)
Author:Jones, G (Professor Graeme Jones)
ID Code:38107
Year Published:2005
Web of Science® Times Cited:197
Deposited By:Menzies Institute for Medical Research
Deposited On:2005-08-01
Last Modified:2007-10-11
Downloads:0

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