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A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis


Srikanth, V and Fryer, JL and Zhai, G and Winzenberg, TM and Hosmer, D and Jones, G, A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis, Osteoarthritis and Cartilage, 13, (9) pp. 769-781. ISSN 1063-4584 (2005) [Refereed Article]

DOI: doi:10.1016/j.joca.2005.04.014


Objective: To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. Methods: Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity. Meta-regression was used to investigate sources of heterogeneity. Results: Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53-0.75] and hand [RR 0.81, 95% CI 0.73-0.90] but not for other sites. Males aged <55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18-1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32-0.94] and hip [IRR 0.64, 95% CI 0.48-0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35-1.20]. Females, particularly those ≥55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition. Conclusions: The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
UTAS Author:Fryer, JL (Ms Jayne Fryer)
UTAS Author:Zhai, G (Dr Guangju Zhai)
UTAS Author:Winzenberg, TM (Professor Tania Winzenberg)
UTAS Author:Hosmer, D (Professor David Hosmer)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:38105
Year Published:2005
Web of Science® Times Cited:657
Deposited By:Menzies Institute for Medical Research
Deposited On:2005-08-01
Last Modified:2012-04-20

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