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Spinal cord tissue affects ensheathing cell proliferation and apoptosis


Woodhouse, A and Vincent, AJ and Kozel, MA and Chung, RS and Waite, PME and Vickers, JC and West, AK and Chuah, MI, Spinal cord tissue affects ensheathing cell proliferation and apoptosis, NeuroReport, 16, (7) pp. 737-740. ISSN 0959-4965 (2005) [Refereed Article]

DOI: doi:10.1097/00001756-200505120-00016


This study investigates proliferation and apoptosis of olfactory ensheathing cells in cocultures with spinal cord tissue. Proliferation of ensheathing cells was significantly increased when cocultured with expiants from uninjured spinal cord, and spinal cord that had been subjected to chronic contusion or chronic needle stab injury, but not to acute needle stab injury. Proliferation rate was highest in cocultures with chronically stabbed cord tissue. Contaminating (p75NGFR-negative) cells in the cultures showed a significantly higher proliferation rate than ensheathing cells. Apoptosis of ensheathing cells was significantly increased in cocultures with acutely stabbed spinal cord expiants compared with chronically contused spinal cord expiants. These results suggest that delaying transplantation after spinal cord injury may be beneficial to ensheathing cell survival. © 2005 Lippincott Williams & Wilkins.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Woodhouse, A (Dr Adele Woodhouse)
UTAS Author:Vincent, AJ (Dr Adele Vincent)
UTAS Author:Chung, RS (Associate Professor Roger Chung)
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:West, AK (Professor Adrian West)
UTAS Author:Chuah, MI (Associate Professor Inn Chuah)
ID Code:38058
Year Published:2005
Web of Science® Times Cited:14
Deposited By:Anatomy and Physiology
Deposited On:2005-08-01
Last Modified:2006-03-31

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