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Spinal cord tissue affects ensheathing cell proliferation and apoptosis

journal contribution
posted on 2023-05-16, 17:28 authored by Adele WoodhouseAdele Woodhouse, Vincent, AJ, Kozel, MA, Chung, RS, Waite, PME, James VickersJames Vickers, Adrian WestAdrian West, Meng Inn ChuahMeng Inn Chuah
This study investigates proliferation and apoptosis of olfactory ensheathing cells in cocultures with spinal cord tissue. Proliferation of ensheathing cells was significantly increased when cocultured with expiants from uninjured spinal cord, and spinal cord that had been subjected to chronic contusion or chronic needle stab injury, but not to acute needle stab injury. Proliferation rate was highest in cocultures with chronically stabbed cord tissue. Contaminating (p75NGFR-negative) cells in the cultures showed a significantly higher proliferation rate than ensheathing cells. Apoptosis of ensheathing cells was significantly increased in cocultures with acutely stabbed spinal cord expiants compared with chronically contused spinal cord expiants. These results suggest that delaying transplantation after spinal cord injury may be beneficial to ensheathing cell survival. © 2005 Lippincott Williams & Wilkins.

History

Publication title

NeuroReport

Volume

16

Issue

7

Pagination

737-740

ISSN

0959-4965

Department/School

Tasmanian School of Medicine

Publisher

Lippincott Williams & Wilkins

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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