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Metallothionein biology in the ageing and neurodegenerative brain


Dittman, J and Fung, SJ and Vickers, JC and Chuah, MI and Chung, RS and West, AK, Metallothionein biology in the ageing and neurodegenerative brain, Neurotoxicity Research, 7, (1, 2) pp. 87-93. ISSN 1029-8428 (2005) [Refereed Article]

DOI: doi:10.1007/BF03033779


In recent years metallothionein (MT) biology has moved from investigation of its ability to protect against environmental heavy metals to a wider appreciation of its role in responding to cellular stress, whether as a consequence of normal function, or following injury and disease. This is exemplified by recent investigation of MT in the mammalian brain where plausible roles for MT action have been described, including zinc metabolism, free radical scavenging, and protection and regeneration following neurological injury. Along with other laboratories we have used several models of central nervous system (CNS) injury to investigate possible parallels between injury-dependent changes in MT expression and those observed in the ageing and/or degenerating brain. Therefore, this brief review aims to summarise existing information on MT expression during CNS ageing, and to examine the possible involvement of this protein in the course of human neurodegenerative disease, as exemplified by Alzheimer's disease. © Springer 2005.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dittman, J (Mr Justin Dittman)
UTAS Author:Fung, SJ (Miss Samantha Fung)
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:Chuah, MI (Associate Professor Inn Chuah)
UTAS Author:Chung, RS (Associate Professor Roger Chung)
UTAS Author:West, AK (Professor Adrian West)
ID Code:38055
Year Published:2005
Web of Science® Times Cited:23
Deposited By:Anatomy and Physiology
Deposited On:2005-08-01
Last Modified:2006-03-31

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