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A differing pattern of association between dietary fish and allergen-specific subgroups of atopy


Andreasyan, K and Ponsonby, AL and Dwyer, T and Kemp, A and Dear, K and Cochrane, JA and Carmichael, A, A differing pattern of association between dietary fish and allergen-specific subgroups of atopy, Allergy, 60, (5) pp. 671-677. ISSN 0105-4538 (2005) [Refereed Article]

DOI: doi:10.1111/j.1398-9995.2005.00757.x


Background: We examined the role of fish intake in the development of atopic disease with particular reference to the possibility of differential effects on allergen-specific subgroups of sensitization. Methods: The exposure of interest was parental report of fish intake by children aged 8 years at the 1997 Childhood Allergy and Respiratory Health Study (n = 499). The outcomes of interest were subgroups of atopy: house dust mite (HDM)-pure sensitization [a positive skin-prick test (SPT) ≥2 mm to Der p or Der f only], ryegrass-pure sensitization (a positive SPT ≥2 mm to ryegrass only); asthma and hay fever by allergen-specific sensitization. Results: A significant association between fish intake and ryegrass-pure [adjusted odds ratio (AOR) 0.37 (0.15-0.90)] but not HDM-pure sensitization [AOR 0.87 (0.36-2.13)] was found. Fish consumption significantly decreased the risk for ryegrass-pure sensitization in comparison with HDM-pure sensitization [AOR 0.20 (0.05-0.79)]. Conclusions: We have demonstrated a differential effect of fish intake for sensitization to different aeroallergens. This may be due to the different timing of allergen exposure during early life. Further investigation of the causes of atopic disease should take into account allergen-specific subgroups. Copyright © Blackwell Munksgaard 2005.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ponsonby, AL (Professor Anne Ponsonby)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Cochrane, JA (Mrs Jennifer Cochrane)
UTAS Author:Carmichael, A (Professor Allan Carmichael)
ID Code:37903
Year Published:2005
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2005-08-01
Last Modified:2006-04-08

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