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Knee structural alteration and BMI: A cross-sectional study

Citation

Ding, C and Cicuttini, F and Scott, F and Cooley, HM and Jones, G, Knee structural alteration and BMI: A cross-sectional study, Obesity Research, 13, (2) pp. 350-361. ISSN 1071-7323 (2005) [Refereed Article]

DOI: doi:10.1038/oby.2005.47

Abstract

Objective: To describe the associations among BMI, knee cartilage morphology, and bone size in adults. Research Methods and Procedures: A cross-sectional convenience sample of 372 male and female subjects (mean age, 45 years; range, 26 to 61 years) was studied. Knee articular cartilage defect score (0 to 4) and prevalence (defect score of ≥2), volume, and thickness, as well as bone surface area and/or volume, were determined at the patellar, tibial, and femoral sites using T1-weighted fat-saturation magnetic resonance imaging. Height, weight, BMI, and radiographic osteoarthritis were measured by standard protocols. Results: In multivariate analysis in the whole group, BMI was significantly associated with knee cartilage defect scores (β: +0.016/kg/m2 to +0.083/kg/m2, all p < 0.05) and prevalence (odds ratio: 1.05 to 1.12/kg/m2, all p < 0.05 except for the lateral tibiofemoral compartment). In addition, BMI was negatively associated with patellar cartilage thickness only (β = -0.021 mm/kg/m 2; p = 0.039) and was positively associated with tibial bone area (medial: β = +7.1 mm2/kg/m2, p = 0.001; lateral: β= +3.2 mm2/kg/ m2, p -0.037). Those who were obese also had higher knee cartilage defect severity and prevalence and larger medial tibial bone area but no significant change in cartilage volume or thickness compared with those of normal weight. Discussion: This study suggests that knee cartilage defects and tibial bone enlargement are the main structural changes associated with increasing BMI particularly in women. Preventing these changes may prevent knee osteoarthritis in overweight and obese subjects. Copyright © 2005 NAASO.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Scott, F (Dr Fiona Scott)
Author:Cooley, HM (Dr Helen Cooley)
Author:Jones, G (Professor Graeme Jones)
ID Code:37902
Year Published:2005
Web of Science® Times Cited:90
Deposited By:Menzies Institute for Medical Research
Deposited On:2005-08-01
Last Modified:2007-10-11
Downloads:0

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