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Central Corneal Thickness Is Highly Heritable: The Twin Eye Studies


Toh, TY and Liew, SHM and MacKinnon, JR and Hewitt, AW and Poulsen, JL and Spector, TD and Gilbert, CE and Craig, JE and Hammond, CJ and Mackey, DA, Central Corneal Thickness Is Highly Heritable: The Twin Eye Studies, Investigative Ophthalmology & Visual Science, 46, (10) pp. 3718-3722. ISSN 0146-0404 (2005) [Refereed Article]

DOI: doi:10.1167/iovs.04-1497


PURPOSE. A classic twin study was performed to determine the heritability of central corneal thickness (CCT), an important parameter in glaucoma assessment. METHODS. The concordance of CCT between monozygotic (MZ) and dizygotic (DZ) twins was compared. A total of 256 twin pairs (131 MZ and 125 DZ) were recruited from three centers: the Twin Eye Study in Tasmania, the Brisbane Adolescent Twin Study, and the Twins U.K. Adult Registry held at St. Thomas' Hospital in London. As part of an extensive ophthalmic evaluation, CCT was measured by ultrasound pachymetry, Structural equation modeling with the Mx program (Department of Psychiatry, Medical College of Virginia, Richmond, VA) was used to determine the heritability of CCT. RESULTS. The mean age of subjects was 38 years (range, 8-81). The mean CCT of all eyes examined was 544.5 ± 37.3 μm (SD). The CCT measurements correlated more highly in MZ twins than in DZ twins, with intraclass correlation coefficients of 0.95 and 0.52, respectively, suggesting a strong genetic influence. A model of additive genetic and unique environmental effects provided the best fit, yielding a heritability of 0.95 (95% confidence interval [CI], 0.93-0.96) with the remaining variation being attributable to unique environmental factors. CONCLUSIONS. In this study of Australian and U.K. twins, genetic factors were shown to be of major importance in CCT, with a heritability of 0.95. Copyright © Association for Research in Vision and Ophthalmology.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Toh, TY (Dr Tze'Yo Toh)
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Mackey, DA (Professor David Mackey)
ID Code:37044
Year Published:2005
Web of Science® Times Cited:111
Deposited By:Medicine
Deposited On:2005-08-01
Last Modified:2016-11-30

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