eCite Digital Repository

Vitamin D insufficiency in adolescent males in Southern Tasmania: prevalence, determinants, and relationship to bone turnover markers


Jones, G and Dwyer, T and Hynes, K and Parameswaran, V and Greenaway, TM, Vitamin D insufficiency in adolescent males in Southern Tasmania: prevalence, determinants, and relationship to bone turnover markers, Osteoporosis international , 16, (6) pp. 636-641. ISSN 0937-941X (2005) [Refereed Article]

DOI: doi:10.1007/s00198-004-1733-z


There are limited data on vitamin D insufficiency in healthy children. The aim of this study was to describe the prevalence and determinants of vitamin D insufficiency and its association with bone turnover in adolescent boys (N=136, mean age 16 years). Sun exposure and physical activity were assessed by questionnaire. Vitamin D stores were assessed by serum 25-hydroxyvitamin D 3 (25[OH]D 3). Bone turnover was assessed by bone-specific alkaline phosphatase (BAP) and urinary pyridinoline (PYR) to creatinine (Cr) ratio (mmol PYR/μmol Cr). The mean 25(OH)D 3 level was low (44 nmol/l; 68% <50 nmol/l; range, 16-87) and was associated with self-reported sun exposure on winter weekends (r=0.23, p=0.01), school holidays (r=0.22, p=0.01), and weekdays (r=0.17, p=0.05). It was also associated with number of sports (r=0.34, p<0.001) and vigorous activity (r=0.22, p=0.01) but not television, computer, and video watching (r=-0.04, p=0.68). In multivariate analysis, number of sports but not total sun exposure remained significantly associated with 25(OH)D 3. Furthermore, 25(OH)D 3 was significantly associated with BAP in cutpoint analysis (cutpoint 55 nmol/l, p=0.03) but not continuous analysis (r=-0.12, p=0.16) and PYR in both forms (r=-0.23, p=0.01, cutpoint 43 nmol/l, p=0.01). In conclusion, vitamin D insufficiency is common in healthy adolescent boys in winter in our setting, is primarily derived from sports-related sun exposure, and is associated with bone turnover markers. These data suggest that a 25(OH)D 3 level of at least 43-55 nmol/l is required for optimal bone health in children. © International Osteoporosis Foundation and National Osteoporosis Foundation 2004.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Clinical sciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Hynes, K (Dr Kristen Hynes)
UTAS Author:Parameswaran, V (Associate Professor Venkat Parameswaran)
UTAS Author:Greenaway, TM (Dr Tim Greenaway)
ID Code:37011
Year Published:2005
Web of Science® Times Cited:73
Deposited By:Medicine
Deposited On:2005-08-01
Last Modified:2006-05-12

Repository Staff Only: item control page