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Quantitation of suspected allergens in fragrances (Part 1): evaluation of comprehensive two-dimensional gas chromatography for quality control
journal contribution
posted on 2023-05-16, 17:09 authored by Robert ShellieRobert Shellie, Marriott, PJ, Chaintreau, AAn evaluation of comprehensive two-dimensional (2D) gas chromatography (GC×GC) was performed to assess its suitability for the analysis of volatile fragrance components, recognized by the European Commission's Scientific Committee on Cosmetics and other Non-food Products (SCCNFP) as possible skin sensitizers. The 24 volatile components listed by the SCCNFP were baseline-resolved or better within one 30 min analysis. High-quality calibration data for standard mixtures were obtained, with R2 > 0.998 over the concentration range 2-1000 mg/l. However, the analysis of small spiked amounts of target compounds in truly complex fragrances was problematic, due to uncertainty in component assignment. The benefits and limitations of GC×GC are reported, and a discussion of the proposed directions for the solution of this analysis is provided. Copyright © 2004 John Wiley & Sons, Ltd. Copyright © 2004 John Wiley & Sons, Ltd.
History
Publication title
Flavour and Fragrance JournalVolume
19Pagination
91-98ISSN
0882-5734Department/School
School of Natural SciencesPublisher
WileyPlace of publication
ChichesterRepository Status
- Restricted