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Comprehensive Two-Dimensional Gas Chromatography with Fast Enantioseparation

Citation

Shellie, RA and Marriott, P, Comprehensive Two-Dimensional Gas Chromatography with Fast Enantioseparation, Analytical Chemistry, 74, (20) pp. 5426-5430. ISSN 0003-2700 (2002) [Refereed Article]

DOI: doi:10.1021/ac025803e

Abstract

The development of fast chiral analysis for use in comprehensive two-dimensional gas chromatography in which a short second dimension enantioselective capillary column provides a route to precise measurement of chiral ratios of enantiomers is described. Retention times as short as 8 s are reported for (±)-limonene, with adequate enantioseparation maintained (Rs ∼ 1.0) on a 1-m cyclodextrin derivative-coated capillary column. Sufficiently fast elution on the second column was achieved by using GC/MS in which the subambient pressure (vacuum outlet) conditions promote increased diffusion coefficients and higher component volatility; a 4-fold reduction of second-dimension retention time was observed, as compared with ambient pressure outlet conditions. The enantiomeric distribution of several monoterpene compounds in bergamot essential oil is reported as a demonstration of the method. Total analysis time of the target components was ∼8.5 min.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Manufacturing
Objective Group:Instrumentation
Objective Field:Scientific Instruments
Author:Shellie, RA (Associate Professor Robert Shellie)
ID Code:36263
Year Published:2002
Web of Science® Times Cited:85
Deposited By:Chemistry
Deposited On:2007-11-02
Last Modified:2007-11-02
Downloads:0

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