The development of fast chiral analysis for use in comprehensive two-dimensional gas chromatography in which a short second dimension enantioselective capillary column provides a route to precise measurement of chiral ratios of enantiomers is described. Retention times as short as 8 s are reported for (±)-limonene, with adequate enantioseparation maintained (Rs ∼ 1.0) on a 1-m cyclodextrin derivative-coated capillary column. Sufficiently fast elution on the second column was achieved by using GC/MS in which the subambient pressure (vacuum outlet) conditions promote increased diffusion coefficients and higher component volatility; a 4-fold reduction of second-dimension retention time was observed, as compared with ambient pressure outlet conditions. The enantiomeric distribution of several monoterpene compounds in bergamot essential oil is reported as a demonstration of the method. Total analysis time of the target components was ∼8.5 min.

Item Type:	Refereed Article
Research Division:	Chemical Sciences
Research Group:	Analytical Chemistry
Research Field:	Separation Science
Objective Division:	Manufacturing
Objective Group:	Instrumentation
Objective Field:	Scientific Instruments
UTAS Author:	Shellie, RA (Associate Professor Robert Shellie)
ID Code:	36263
Year Published:	2002
Web of Science® Times Cited:	89
Deposited By:	Chemistry
Deposited On:	2007-11-02
Last Modified:	2007-11-02
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