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In comprehensive 2D gas chromatography, the entire sample is simultaneously subjected to analysis on two capillary columns. By using a suitable modulation interface between the primary and secondary columns, hundreds of fast, second-dimension chromatograms are produced. The data from these chromatograms are treated such that a 3D surface plot or a 2D contour plot of the components' individual retention times, on each column, as well as peak responses, are represented. In a properly tuned comprehensive 2D chromatogram, the individual sample components are spread throughout a 2D separation space, providing a significant increase in the probability of resolving a greater number of sample components without increasing the analysis time. Comprehensive 2D-GC has proved useful for high-resolution conventional essential oil analysis as well as high-resolution enantioselective essential oil analysis. Combining comprehensive 2D-GC with either a quadrupole or time-of-flight mass spectrometer gives a powerful 3D analysis technique, which is extremely effective for complex sample analysis. The present status and opportunities arising from these ultra-high resolution approaches are discussed herein.

Item Type:	Refereed Article
Keywords:	comprehensive two-dimensional gas chromatography • GC × GC • high resolution • essential oils • enantioselective analysis • mass spectrometry
Research Division:	Chemical Sciences
Research Group:	Analytical Chemistry
Research Field:	Separation Science
Objective Division:	Manufacturing
Objective Group:	Instrumentation
Objective Field:	Scientific Instruments
Author:	Shellie, RA (Associate Professor Robert Shellie)
ID Code:	36246
Year Published:	2003
Web of Science® Times Cited:	52
Deposited By:	Chemistry
Deposited On:	2007-11-02
Last Modified:	2010-03-16
Downloads:	1 View Download Statistics