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Biological dust exposure in the workplace is a risk factor for Chronic Obstructive Pulmonary Disease

Citation

Matheson, MC and Benke, G and Raven, J and Sim, MR and Kromhout, H and Vermeulen, R and Johns, DP and Walters, EH and Abramson, MJ, Biological dust exposure in the workplace is a risk factor for Chronic Obstructive Pulmonary Disease, Thorax, 60, (8) pp. 645-651. ISSN 0040-6376 (2005) [Refereed Article]

DOI: doi:10.1136/thx.2004.035170

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Although the main risk factor is smoking, 15-19% of COPD even in smokers has been attributed to occupational exposures. The aim of this study was to investigate the association between occupational exposure and risk of COPD. Methods: Participants were part of a cross sectional study of risk factors for COPD. A total of 1232 completed a detailed respiratory questionnaire, spirometric testing and measurement of gas transfer. Job histories were coded according to the International Standard Classification of Occupations. These codes were then used to establish occupational exposures using the ALOHA job exposure matrix. Results: The prevalence of emphysema was 2.4%, chronic obstructive bronchitis 1.8%, and COPD 3.4%. Subjects ever exposed to biological dusts had an increased risk of chronic obstructive bronchitis (OR 3.19; 95% CI 1.27 to 7.97), emphysema (OR 3.18; 95% CI 1.41 to 7.13), and COPD (OR 2.70, 95% CI 1.39 to 5.23). These risks were higher in women than in men. For biological dust, the risk of emphysema and COPD was also significantly increased in both the duration of exposure categories, again in women but not in men. No significant increased risks for COPD were found for mineral dust (OR 1.13; 95% CI 0.57 to 2.27) or gases/fumes (OR 1.63; 95% CI 0.83 to 3.22). Conclusion: In this general population sample of adults, occupational exposures to biological dusts were associated with an increased risk of COPD which was higher in women. Preventive strategies should be aimed at reducing exposure to these agents in the workplace.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Johns, DP (Associate Professor David Johns)
Author:Walters, EH (Professor Haydn Walters)
ID Code:35866
Year Published:2005
Web of Science® Times Cited:132
Deposited By:Medicine (Discipline)
Deposited On:2005-08-01
Last Modified:2011-11-30
Downloads:0

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