eCite Digital Repository

Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice. ASPirin in Reducing Events in the Elderly (ASPREE)

Citation

Nelson, MR and Reid, CM and Beilin, LJ and Donnan, GA and Johnston, CI and Krum, H and Storey, E and Tonkin, AM and McNeil, JJ, Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice. ASPirin in Reducing Events in the Elderly (ASPREE), Drugs and Aging, 20, (12) pp. 897-903. ISSN 1170-229X (2002) [Refereed Article]

DOI: doi:10.2165/00002512-200320120-00004

Abstract

Low-dose aspirin (acetylsalicylic acid) therapy has been shown to reduce the risk of vascular events and there is increasing evidence of its potential to reduce the rate of cognitive decline in the elderly. Adverse effects including gastrointestinal and intracranial haemorrhage may offset these benefits. The balance of risks versus benefits of aspirin for the primary prevention of cardiovascular disease and vascular dementia has not been established in the elderly. There is clearly a need to conduct a study in family practice to investigate whether routine use of low-dose aspirin for the primary prevention of cardiovascular disease and vascular dementia in the elderly is beneficial or harmful. Aspirin in reducing events in the elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin for the primary prevention of major adverse cardiovascular events and vascular dementia. It will follow 15 000 subjects aged 70 years or more for an average of 5 years. This sample size has a power of 87% to detect a 15% reduction in primary events in the aspirin group, with an anticipated combined primary event rate of 20 per 1000 patient years.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Primary Health Care
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Nelson, MR (Professor Mark Nelson)
ID Code:35780
Year Published:2002
Web of Science® Times Cited:40
Deposited By:General Practice
Deposited On:2005-08-31
Last Modified:2005-08-31
Downloads:0

Repository Staff Only: item control page