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Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice

Citation

Roberts, AW and Hasegawa, M and Metcalf, D and Foote, SJ, Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice, Leukemia, 14, (4) pp. 657-661. ISSN 0887-6924 (2000) [Refereed Article]

DOI: doi:10.1038/sj.leu.2401735

Abstract

Clinically detectable splenomegaly and splenic rupture are uncommon but potentially life-threatening consequences of G-CSF administration. Increased spleen size in mice injected with G-CSF is a complex genetic trait amenable to investigation in experimental inter-strain crosses by quantitative trait analysis. A quantitative trait locus (QTL) with highly significant linkage (LCD 7.9) for splenomegaly was identified within a 22 centimorgan (cM) region on chromosome 1. Inheritance of a C57BL/6 haplotype in this region was associated with a greater spleen weight. The relevance of this locus was confirmed by analysing the responses of mice congenic for the distal 12 cM of this region (C57BL/6 and C57BL/6.SJL-Ptprc a Pep3 b ). Consistent with the QTL effect, mice lacking C57BL/6 alleles in this region had reduced splenomegaly induced by G-CSF. Intriguingly, peripheral blood neutrophilia and progenitor cell mobilisation responses to G-CSF were also significantly influenced.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Medical Genetics (excl. Cancer Genetics)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Foote, SJ (Professor Simon Foote)
ID Code:35120
Year Published:2000
Web of Science® Times Cited:15
Deposited By:Menzies Centre
Deposited On:2005-08-01
Last Modified:2011-11-18
Downloads:0

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