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Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in Eu-v-abl transgenic mice

Citation

Symons, RCA and Daly, MJ and Fridlyand, J and Speed, TP and Cook, WD and Gerondakis, S and Harris, AW and Foote, SJ, Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in Eu-v-abl transgenic mice, National Academy of Sciences of The United States of America. Proceedings, 99, (17) pp. 11299-11304. ISSN 0027-8424 (2002) [Refereed Article]

DOI: doi:10.1073/pnas.162566999

Abstract

There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2,4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Medical Genetics (excl. Cancer Genetics)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Foote, SJ (Professor Simon Foote)
ID Code:35065
Year Published:2002
Web of Science® Times Cited:26
Deposited By:Menzies Centre
Deposited On:2005-08-01
Last Modified:2011-11-25
Downloads:0

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