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Leishmaniasis host response loci (Imr1-3) modify disease severity through a Th1/Th2-independent pathway
Citation
Elso, CM and Roberts, LJ and Smyth, GK and Thomson, Russell and Baldwin, TM and Foote, SJ and Handman, E, Leishmaniasis host response loci (Imr1-3) modify disease severity through a Th1/Th2-independent pathway, Genes and Immunity, 5, (2) pp. 93-100. ISSN 1466-4879 (2004) [Refereed Article]
DOI: doi:10.1038/sj.gene.6364042
Abstract
The severity of disease caused by infection with Leishmania major depends critically on the genetics of the host. Early induction of T helper (Th) 1-type immune responses in the resistant C57BL/6 mice and Th2-type responses in the susceptible BALB/c mice are thought to determine cure or disease, respectively. We have previously mapped three host response loci in a genetic cross between C57BL/6 and BALB/c mice, and here we show definitively the involvement of these loci in disease severity using animals congenic for each of the loci. Surprisingly, in the late stage of infection when the difference in disease severity between congenic and parental mice was most pronounced, their cytokine profile correlated with the genetic background of the mice and not with the severity of disease. This indicates that the loci that we have mapped are acting by a mechanism independent of Th phenotype. © 2004 Nature Publishing Group All rights reserved.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Infectious diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Thomson, Russell (Dr Russell Thomson) |
UTAS Author: | Foote, SJ (Professor Simon Foote) |
ID Code: | 35034 |
Year Published: | 2004 |
Web of Science® Times Cited: | 86 |
Deposited By: | Menzies Centre |
Deposited On: | 2005-08-01 |
Last Modified: | 2011-08-24 |
Downloads: | 0 |
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