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Ages of mutations on a coalescent tree

Citation

Thomson, RJ, Ages of mutations on a coalescent tree, Mathematical Biosciences, 153, (1) pp. 41-61. ISSN 0025-5564 (1998) [Refereed Article]

DOI: doi:10.1016/S0025-5564(98)10029-9

Abstract

Using the coalescent process, DNA sequences of a sample of individuals can be used to study the phylogenetic history of the individuals. Under the infinitely-many-sites mutation model, the DNA sequence data can be summarized by the number of segregating sites (which is numerically equivalent to the number of mutations on the tree). A number of methods exist, including a recursive method presented in this paper, that obtain an estimate of the age of the most recent common ancestor (MRCA), given the number of mutations. This paper introduces a method for finding the ages of mutations, given the total number of mutations on the tree. While the result is not useful in estimating the age of a specific segregating site, it is useful in examining the underlying assumption of a relatively constant population over time. This utilization of the result is illustrated using DNA sequence data obtained from a sample of Amerindians of the Nuu-Chah-Nulth tribe.

Item Details

Item Type:Refereed Article
Research Division:Mathematical Sciences
Research Group:Applied Mathematics
Research Field:Biological Mathematics
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Mathematical Sciences
Author:Thomson, RJ (Dr Russell Thomson)
ID Code:34890
Year Published:1998
Web of Science® Times Cited:2
Deposited By:Menzies Centre
Deposited On:2007-05-29
Last Modified:2011-08-10
Downloads:0

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