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Recent common ancestry of human Y chromosomes: evidence from DNA sequence data

Citation

Thomson, RJ and Pritchard, JK and Shen, P and Oefner, PJ and Feldman, MW, Recent common ancestry of human Y chromosomes: evidence from DNA sequence data, Proceedings of the National Academy of Sciences, 97, (13) pp. 7360-7365. ISSN 0027-8424 (2000) [Refereed Article]

DOI: doi:10.1073/pnas.97.13.7360

Abstract

We consider a data set of DNA sequence variation at three Y chromosome genes (SMCY, DBY, and DFFRY) in a worldwide sample of human Y chromosomes. Between 53 and 70 chromosomes were fully screened for sequence variation at each locus by using the method of denaturing high-performance liquid chromatography. The sum of the lengths of the three genes is 64,120 bp. We have used these data to study the ancestral genealogy of human Y chromosomes. In particular, we focused on estimating the expected time to the most recent common ancestor and the expected ages of certain mutations with interesting geographic distributions. Although the geographic structure of the inferred haplotype tree is reminiscent of that obtained for other loci (the root is in Africa, and most of the oldest non-African lineages are Asian), the expected time to the most recent common ancestor is remarkably short, on the order of 50,000 years. Thus, although previous studies have noted that Y chromosome variation shows extreme geographic structure, we estimate that the spread of Y chromosomes out of Africa is much more recent than previously was thought. We also show that our data indicate substantial population growth in the effective number of human Y chromosomes.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Anthropological Genetics
Objective Division:Cultural Understanding
Objective Group:Understanding Past Societies
Objective Field:Understanding Past Societies not elsewhere classified
Author:Thomson, RJ (Dr Russell Thomson)
ID Code:34689
Year Published:2000
Web of Science® Times Cited:205
Deposited By:Menzies Centre
Deposited On:2007-05-29
Last Modified:2007-05-29
Downloads:0

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