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Could mitochondrial dysfunction play a role in manganese toxicity
journal contribution
posted on 2023-05-16, 16:17 authored by Brown, SC, Taylor, NLIndividuals suffering from manganese toxicity exhibit several symptoms, including mitochondrial dysfunction, which are similar to those frequently observed in cases of Parkinson's disease. We review the literature concerning manganese toxicity and mitochondrial function, and propose a simple conceptual model of the aetiology of manganese toxicity which involves an interaction between inhibition of mitochondrial energy transduction, generation of free radicals and mutations of the mitochondrial genome. This conceptual model prompts a number of relatively simple experiments which would provide a test of the model. Copyright (C) 1999 Elsevier Science B.V.
History
Publication title
Environmental Toxicology and PharmacologyVolume
7Pagination
49-57ISSN
1382-6689Department/School
School of Health SciencesPublisher
Environmental Toxicology and PharmacologyPlace of publication
AustraliaRepository Status
- Restricted