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Could mitochondrial dysfunction play a role in manganese toxicity

Citation

Brown, SC and Taylor, NL, Could mitochondrial dysfunction play a role in manganese toxicity, Environmental Toxicology and Pharmacology, 7, (1) pp. 49-57. ISSN 1382-6689 (1999) [Refereed Article]

DOI: doi:10.1016/S1382-6689(98)00054-4

Abstract

Individuals suffering from manganese toxicity exhibit several symptoms, including mitochondrial dysfunction, which are similar to those frequently observed in cases of Parkinson's disease. We review the literature concerning manganese toxicity and mitochondrial function, and propose a simple conceptual model of the aetiology of manganese toxicity which involves an interaction between inhibition of mitochondrial energy transduction, generation of free radicals and mutations of the mitochondrial genome. This conceptual model prompts a number of relatively simple experiments which would provide a test of the model. Copyright (C) 1999 Elsevier Science B.V.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Enzymes
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Brown, SC (Dr Simon Brown)
ID Code:33101
Year Published:1999
Web of Science® Times Cited:22
Deposited By:Health Sciences A
Deposited On:2005-06-22
Last Modified:2011-08-05
Downloads:0

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